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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Zmpste24
zinc metallopeptidase, STE24
MGI:1890508
77 phenotypes from 2 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Zmpste24tm1Otin/Zmpste24tm1Otin
involves: 129P2/Ola * C57BL/6 		abnormal body weight J:76209
abnormal femur morphology J:76209
abnormal hair follicle morphology J:76209
abnormal locomotor behavior J:76209
abnormal postural reflex J:76209
abnormal thymus corticomedullary boundary morphology J:76209
abnormal tibia morphology J:76209
absent subcutaneous adipose tissue J:76209
cardiac interstitial fibrosis J:76209
decreased body size J:76209
dilated cardiomyopathy J:76209
dilated heart left ventricle J:76209
dilated heart right ventricle J:76209
dystrophic muscle J:76209
epidermal atrophy J:76209
hunched posture J:76209
increased circulating aspartate transaminase level J:76209
increased circulating creatine kinase level J:76209
increased circulating glutamate dehydrogenase level J:76209
increased hair follicle apoptosis J:76209
increased heart weight J:76209
increased kidney weight J:76209
postnatal growth retardation J:76209
premature death J:76209
premature hair loss J:76209
scoliosis J:76209
thin ventricular wall J:76209
thymus hypoplasia J:76209
tremors J:76209
weight loss J:76209
Zmpste24tm1Otin/Zmpste24tm1Otin
involves: 129P2/OlaHsd 		alopecia J:164373
decreased body weight J:164373
decreased circulating insulin-like growth factor I level J:164373
decreased subcutaneous adipose tissue amount J:164373
increased circulating growth hormone level J:164373
kyphosis J:164373
premature aging J:164373
premature death J:164373
Zmpste24tm1Sgy/Zmpste24+
involves: 129S4/SvJae * C57BL/6 		abnormal lumbar vertebrae morphology J:79501
abnormal thoracic vertebrae morphology J:79501
alopecia J:79501
weakness J:79501
weight loss J:79501
Zmpste24tm1Sgy/Zmpste24tm1Sgy
B6.129S4-Zmpste24tm1Sgy 		abnormal grip strength J:106706
extended life span J:106706
fragile skeleton J:106706
increased susceptibility to weight gain J:106706
Zmpste24tm1Sgy/Zmpste24tm1Sgy
involves: 129S4/SvJae 		abnormal skeleton morphology J:160705
aphagia J:160705
decreased body weight J:160705, J:165928
decreased survivor rate J:160705
postnatal lethality, complete penetrance J:165928
premature death J:160705
rib fractures J:160705, J:165928
Zmpste24tm1Sgy/Zmpste24tm1Sgy
involves: 129S4/SvJae * C57BL/6 		abnormal axial skeleton morphology J:79501
abnormal bone structure J:79501
abnormal cell nucleus morphology J:95274, J:106473
abnormal cell physiology J:79501
abnormal cranial suture morphology J:79501, J:95274
abnormal craniofacial bone morphology J:79501
abnormal fibula morphology J:79501
abnormal gait J:79501
abnormal grip strength J:95274, J:106473
abnormal incisor morphology J:95274
abnormal long bone morphology J:79501
abnormal lower incisor morphology J:79501
abnormal mandible morphology J:95274
abnormal rib morphology J:95274
abnormal skeleton physiology J:79501
abnormal thoracic vertebrae morphology J:79501
abnormal tibia morphology J:79501
abnormal trabecular bone morphology J:79501
abnormal zygomatic arch morphology J:79501
abnormal zygomatic bone morphology J:95274
alopecia J:79501
cachexia J:79501
normal cardiovascular system phenotype J:79501
decreased bone mineral density of presacral vertebrae J:79501
decreased circulating glucose level J:79501
decreased circulating total protein level J:79501
decreased compact bone thickness J:79501
decreased grip strength J:79501
decreased subcutaneous adipose tissue amount J:79501
fragile skeleton J:95274, J:106473
kyphosis J:79501
normal liver/biliary system phenotype J:79501
long lower incisors J:79501
micrognathia J:79501
postnatal growth retardation J:79501, J:95274, J:106473
premature death J:79501, J:106473
progressive muscle weakness J:79501, J:95274
rib fractures J:79501
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory