Lin28a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lin28a
lin-28 homolog A
MGI:1890546

70 phenotypes from 6 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Col1a1^{tm1(tetO-Lin28a)Gqda}/Col1a1⁺ involves: 129S4/SvJae * C57BL/6 * CD-1	abnormal digestive system morphology	J:166568
	abnormal skeleton morphology	J:166568
	big ears	J:166568
	broad face	J:166568
	coarse hair	J:166568
	decreased circulating glucose level	J:166568
	decreased circulating insulin level	J:166568
	decreased susceptibility to age related obesity	J:177113
	decreased susceptibility to diet-induced hepatic steatosis	J:177113
	decreased susceptibility to diet-induced obesity	J:177113
	decreased total body fat amount	J:177113
	delayed female fertility	J:166568
	delayed sexual maturation	J:166568
	delayed vaginal opening	J:166568
	improved glucose tolerance	J:166568, J:177113
	increased body length	J:166568
	increased body size	J:166568
	increased body weight	J:166568
	increased bone mineral content	J:166568
	increased bone mineral density	J:166568
	increased cell proliferation	J:166568
	increased growth rate	J:166568
	increased hepatocyte proliferation	J:166568
	increased insulin sensitivity	J:166568, J:177113
	increased lean body mass	J:177113
	increased litter size	J:166568
	liver hyperplasia	J:166568
	premature death	J:166568
	normal reproductive system phenotype	J:166568
	skin hyperplasia	J:166568
	small pancreatic islets	J:166568
	thick skin	J:166568
Lin28a^tm1.1Gqda/Lin28a^tm1.1Gqda involves: 129S4/SvJae * C57BL/6	abnormal cell physiology	J:199720
	abnormal glucose homeostasis	J:199720
	decreased body length	J:199720
	decreased body size	J:199720
	decreased body weight	J:199720
	decreased bone mineral density	J:199720
	decreased embryo weight	J:199720
	decreased fetal weight	J:199720
	decreased total body fat amount	J:199720
	normal muscle phenotype	J:199720
	neonatal lethality, incomplete penetrance	J:199720
	ventricular septal defect	J:199720
Lin28a^tm1.1Gqda/Lin28a^tm1.1Gqda involves: 129S4/SvJae * C57BL/6 * FVB	decreased germ cell number	J:196313
	reduced fertility	J:196313
Lin28a^tm1.2Gqda/Lin28a^tm1.2Gqda STOCK Lin28a^tm1.2Gqda/J	no abnormal phenotype detected	J:101977
Lin28a^tm1Egm/Lin28a^tm1Egm involves: 129S/SvEv	decreased birth weight	J:166568
Lin28a^tm1Egm/Lin28a^tm1Egm involves: 129S/SvEv	postnatal lethality, complete penetrance	J:166568
Lin28a^tm1Egm/Lin28a^tm1Egm involves: 129S/SvEv * C57BL/6NTac	decreased body size	J:196313
	decreased body weight	J:196313
	decreased circulating follicle stimulating hormone level	J:196313
	decreased circulating testosterone level	J:196313
	decreased germ cell number	J:196313
	decreased litter size	J:196313
	decreased oocyte number	J:196313
	decreased ovary weight	J:196313
	decreased primordial germ cell number	J:196313
	decreased primordial ovarian follicle number	J:196313
	oligozoospermia	J:196313
	reduced female fertility	J:196313
	reduced male fertility	J:196313
	reduced male mating frequency	J:196313
Lin28a^tm1Gqda/Lin28a^tm1.1Gqda Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N	decreased body length	J:199720
	decreased body size	J:199720
	normal growth/size/body region phenotype	J:199720
Lin28a^tm1Gqda/Lin28a^tm1Gqda Myf5^tm1(cre)Mrc/Myf5⁺ involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	normal growth/size/body region phenotype	J:199720
Lin28a^tm1Gqda/Lin28a^tm1Gqda Myf5^tm3(cre)Sor/Myf5⁺ involves: 129S4/SvJae * C57BL/6 * CD-1	impaired glucose tolerance	J:177113
	insulin resistance	J:177113
Tg(Cdh16-cre)91Igr/0 Tg(EIF1AX-Lin28a)#Gqda/0 involves: 129S4/SvJae * C57BL/6 * ICR	normal neoplasm	J:211179
Tg(Ddx4-cre)1Dcas/0 Tg(EIF1AX-Lin28a)#Gqda/0 involves: 129S4/SvJae * C57BL/6 * CD-1 * FVB/N	abnormal kidney mesenchyme morphology	J:211179
	abnormal proximal convoluted tubule morphology	J:211179
	delayed kidney development	J:211179
	enlarged kidney	J:211179
	increased kidney tumor incidence	J:211179
	perinatal lethality	J:211179
Tg(EIF1AX-Lin28a)#Gqda/0 Foxd1^{tm1(GFP/cre)Amc}/Foxd1⁺ involves: 129S4/SvJae * C57BL/6	normal neoplasm	J:211179
Tg(EIF1AX-Lin28a)#Gqda/0 Tg(Six2-EGFP/cre)1Amc/0 involves: 129S4/SvJae * C57BL/6 * CD-1	kidney cyst	J:211179
	normal neoplasm	J:211179

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