Actn4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Actn4
actinin alpha 4
MGI:1890773

64 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Actn4^{tm1a(EUCOMM)Wtsi}/Actn4⁺ C57BL/6N-Actn4^{tm1a(EUCOMM)Wtsi}/Wtsi	abnormal retina morphology	J:211773
	increased heart weight	J:211773
Actn4^{tm1a(EUCOMM)Wtsi}/Actn4^{tm1a(EUCOMM)Wtsi} C57BL/6N-Actn4^{tm1a(EUCOMM)Wtsi}/Wtsi	abnormal atrioventricular cushion morphology	J:239583
	abnormal coronary sinus connection	J:239583
	abnormal ductus venosus valve morphology	J:239583
	abnormal ductus venosus valve topology	J:239583
	abnormal eye muscle morphology	J:239583
	abnormal forebrain morphology	J:239583
	abnormal hypoglossal canal morphology	J:239583
	abnormal hypoglossal nerve topology	J:239583
	abnormal inferior vena cava morphology	J:239583
	abnormal infrahyoid muscle connection	J:239583
	abnormal intestine placement	J:239583
	abnormal lens epithelium morphology	J:239583
	abnormal Mullerian duct morphology	J:239583
	abnormal optic cup morphology	J:239583
	abnormal vein morphology	J:239583
	absent ductus venosus valve	J:239583
	absent hypoglossal canal	J:239583
	absent hypoglossal nerve	J:239583
	absent stapedial artery	J:239583
	absent superior cervical ganglion	J:239583
	arteriovenous malformation	J:239583
	biliary cyst	J:239583
	blood in lymph vessels	J:239583
	dilated liver sinusoidal space	J:239583
	double outlet right ventricle	J:239583
	embryo tumor	J:239583
	hemopericardium	J:239583
	heterochrony	J:239583
	increased trigeminal neuroma incidence	J:239583
	multiple persisting craniopharyngeal ducts	J:239583
	muscular ventricular septal defect	J:239583
	overriding aortic valve	J:239583
	perimembraneous ventricular septal defect	J:239583
	persistent dorsal ophthalmic artery	J:239583
	preweaning lethality, incomplete penetrance	J:211773
	short snout	J:239583
	small hypoglossal canal	J:239583
	small superior cervical ganglion	J:239583
	subcutaneous edema	J:239583
	thin hypoglossal nerve	J:239583
Actn4^tm1Mrpk/Actn4^tm1Mrpk involves: 129 * C57BL/6	abnormal blood urea nitrogen level	J:83911
	abnormal glomerular capillary morphology	J:83911
	abnormal lymphocyte chemotaxis	J:83911
	abnormal podocyte adhesion	J:118122
	abnormal renal glomerulus basement membrane morphology	J:83911
	albuminuria	J:83911, J:118122
	cortical renal glomerulopathies	J:83911
	decreased podocyte number	J:118122
	detached podocyte	J:118122
	dilated renal tubule	J:83911
	glomerulosclerosis	J:83911
	increased urine microalbumin level	J:83911
	increased urine protein level	J:90755
	kidney failure	J:83911
	pale kidney	J:83911
	perinatal lethality, incomplete penetrance	J:83911
	podocyte foot process effacement	J:83911
	postnatal growth retardation	J:83911
	premature death	J:83911
	renal cast	J:83911
	small kidney	J:83911
	weight loss	J:83911

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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