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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Zfp423
zinc finger protein 423
MGI:1891217
57 phenotypes from 8 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Zfp423em1(IMPC)J/Zfp423+
C57BL/6NJ-Zfp423em1(IMPC)J/Mmjax 		decreased locomotor activity J:211773
increased circulating alkaline phosphatase level J:211773
persistence of hyaloid vascular system J:211773
Zfp423em1(IMPC)J/Zfp423em1(IMPC)J
C57BL/6NJ-Zfp423em1(IMPC)J/Mmjax 		preweaning lethality, complete penetrance J:211773
Zfp423Gt(pT1Betageo)1Ruiz/Zfp423Gt(pT1Betageo)1Ruiz
involves: 129P2/OlaHsd * C57BL/6 		no abnormal phenotype detected J:85162
Zfp423Gt(XB409)Byg/Zfp423Gt(XB409)Byg
involves: 129P2/OlaHsd * C57BL/6 		abnormal brain interventricular foramen morphology J:122606
abnormal cerebellar plate morphology J:122606
abnormal forebrain morphology J:122606
abnormal medulla oblongata morphology J:122606
ataxia J:122606
decreased body size J:122606
enlarged fourth ventricle J:122606
enlarged lateral ventricles J:122606
neonatal lethality, incomplete penetrance J:122275, J:122606
postnatal lethality, complete penetrance J:122606
Zfp423Gt(XH542)Byg/Zfp423Gt(XH542)Byg
involves: 129P2/OlaHsd * C57BL/6 		normal behavior/neurological phenotype J:111316
Zfp423Gt(XH542)Byg/Zfp423tm1.2Ngc
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * CD-1 		reduced cerebellar foliation J:111316
small cerebellum J:111316
Zfp423nur12/Zfp423Gt(XH542)Byg
involves: 129P2/OlaHsd * BALB/c * C57BL/6 * C3H 		abnormal gait J:114758
cerebellum hypoplasia J:114758
Zfp423nur12/Zfp423nur12
involves: BALB/c * C57BL/6 * C3H 		abnormal cerebellar cortex morphology J:114758
abnormal cerebellum morphology J:114758
abnormal choroid plexus morphology J:114758
abnormal hippocampus morphology J:114758
abnormal telencephalon morphology J:114758
absent corpus callosum J:114758
ataxia J:114758
cerebellum vermis hypoplasia J:114758
decreased body weight J:114758
dilated fourth ventricle J:114758
dilated lateral ventricle J:114758
tremors J:114758
Zfp423nur12/Zfp423nur12
involves: C57BL/6J 		ataxia J:85113
lethality at weaning, complete penetrance J:85113
tremors J:85113
Zfp423tm1.1Ngc/Zfp423tm1.1Ngc
involves: 129S1/Sv * C57BL/6 * CD-1 		no abnormal phenotype detected J:111316
Zfp423tm1.2Ngc/Zfp423tm1.2Ngc
involves: 129S1/Sv * C57BL/6 * CD-1 		abnormal cerebellum morphology J:111316
abnormal cerebellum vermis morphology J:111316
abnormal food intake J:111316
abnormal gait J:111316
abnormal motor coordination/balance J:111316
abnormal Purkinje cell dendrite morphology J:111316
ataxia J:111316
decreased body size J:111316
decreased brain size J:111316
decreased hindbrain size J:111316
dehydration J:111316
ectopic Purkinje cell J:111316
lethality at weaning, incomplete penetrance J:111316
premature death J:111316
reduced cerebellar foliation J:111316
Zfp423tm1Reed/Zfp423tm1Reed
involves: 129 * C57BL/6 		abnormal cerebellar cortex morphology J:122606
abnormal cerebellar granule cell precursor proliferation J:122606
abnormal cerebellum development J:122606
abnormal cerebellum lateral hemisphere morphology J:122606
abnormal corpus callosum morphology J:122606
abnormal forebrain morphology J:122606
abnormal hippocampal commissure morphology J:122606
abnormal Purkinje cell dendrite morphology J:122606
absent cerebellum J:122606
absent cerebellum vermis J:122606
ataxia J:122606
cerebellum vermis hypoplasia J:122606
decreased body weight J:122606
decreased Purkinje cell number J:122606
enlarged lateral ventricles J:122606
postnatal lethality, incomplete penetrance J:122606
premature death J:122606
reduced cerebellar foliation J:122606
small thalamus J:122606
Zfp423tm1Reed/Zfp423tm1Reed
Not Specified 		abnormal cerebellum morphology J:122275
abnormal nasal cavity morphology J:122275
abnormal olfactory bulb morphology J:122275
abnormal olfactory epithelium morphology J:122275
abnormal olfactory nerve morphology J:122275
ataxia J:122275
decreased body size J:122275
lethality at weaning, complete penetrance J:122275
small olfactory bulb J:122275
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory