Lpin1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lpin1
lipin 1
MGI:1891340

94 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Lpin1²⁰⁸⁸⁴/Lpin1²⁰⁸⁸⁴ Nrcam²⁰⁸⁸⁴/Nrcam²⁰⁸⁸⁴ involves: C57BL/6J	abnormal action potential	J:153042
	abnormal gait	J:153042
	abnormal myelin sheath morphology	J:153042
	abnormal nursing	J:153042
	abnormal sciatic nerve morphology	J:153042
	abnormal sexual interaction	J:153042
	decreased body weight	J:153042
	decreased grip strength	J:153042
	decreased joint mobility	J:153042
	decreased nerve conduction velocity	J:153042
	demyelination	J:153042
	hindlimb paralysis	J:153042
	limb grasping	J:153042
	paresis	J:153042
	skeletal muscle fiber atrophy	J:153042
Lpin1²⁰⁸⁸⁴/Lpin1^fld involves: BALB/cByJ * C57BL/6J	abnormal gait	J:153042
	abnormal myelin sheath morphology	J:153042
	abnormal sciatic nerve morphology	J:153042
	limb grasping	J:153042
Lpin1^fld/Lpin1⁺ Lpin2^tm1Reue/Lpin2^tm1Reue involves: BALB/cByJ * C57BL/6J	embryonic growth retardation	J:189894
Lpin1^fld/Lpin1^fld BALB/cByJ-Lpin1^fld	abnormal aorta morphology	J:63448
	abnormal axon morphology	J:82882
	abnormal brown adipose tissue morphology	J:63448
	abnormal brown adipose tissue physiology	J:63448
	abnormal cholesterol homeostasis	J:82882
	abnormal enzyme/coenzyme activity	J:82882
	abnormal epididymal fat pad morphology	J:63448
	abnormal fat cell morphology	J:63448, J:66739
	abnormal gait	J:82882
	abnormal hair growth	J:82882
	abnormal lipid homeostasis	J:82882
	abnormal lipid level	J:82882
	abnormal motor coordination/balance	J:9801
	abnormal myelin sheath morphology	J:82882
	abnormal phospholipid level	J:82882
	abnormal PNS glial cell morphology	J:82882
	abnormal Schwann cell morphology	J:82882
	abnormal sciatic nerve morphology	J:82882
	abnormal triglyceride level	J:82882
	abnormal white adipose tissue physiology	J:63448
	axon degeneration	J:82882
	decreased body weight	J:63448
	decreased brown adipose tissue mass	J:63448, J:66739
	decreased brown fat cell lipid droplet size	J:66739
	decreased circulating LDL cholesterol level	J:63448
	decreased circulating leptin level	J:66739
	decreased circulating VLDL cholesterol level	J:63448
	decreased epididymal fat pad weight	J:63448
	decreased fatty acids level	J:63448
	decreased hormone-sensitive lipase activity	J:63448
	decreased inguinal fat pad weight	J:63448
	decreased insulin secretion	J:63448
	decreased interscapular fat pad weight	J:63448
	decreased lean body mass	J:63448
	decreased lipoprotein lipase activity	J:82882
	decreased survivor rate	J:9801
	decreased triglyceride level	J:82882
	decreased triglyceride lipase activity	J:82882
	decreased white adipose tissue mass	J:63448, J:66739
	decreased white fat cell lipid droplet size	J:66739
	delayed female fertility	J:82882
	disheveled coat	J:82882
	distended abdomen	J:82882
	enlarged liver	J:63448, J:82882
	female infertility	J:82882
	impaired glucose tolerance	J:63448
	impaired limb coordination	J:9801
	increased cholesterol level	J:82882
	increased circulating HDL cholesterol level	J:63448
	increased circulating insulin level	J:63448
	increased circulating triglyceride level	J:82882
	increased circulating VLDL triglyceride level	J:147417
	increased fatty acids level	J:82882
	increased liver triglyceride level	J:82882, J:147417
	increased triglyceride level	J:82882
	insulin resistance	J:63448
	lethality at weaning, incomplete penetrance	J:9801
	limb grasping	J:82882
	male infertility	J:82882
	pale liver	J:82882
	postnatal lethality, incomplete penetrance	J:82882
	premature death	J:82882
	retarded hair growth	J:9801
	ruffled hair	J:82882
tremors	J:82882
Lpin1^fld/Lpin1^fld BALB/cByJ-Lpin1^fld/J	abnormal action potential	J:137213
	abnormal enzyme/coenzyme level	J:121022
	abnormal gluconeogenesis	J:121022
	abnormal glucose homeostasis	J:121022
	abnormal metabolism	J:121022
	abnormal myelination	J:137213
	abnormal respiratory quotient	J:121022
	abnormal sciatic nerve morphology	J:137213
	decreased nerve conduction velocity	J:137213
	increased circulating glucose level	J:121022
	increased fatty acids level	J:121022
	increased glycogen level	J:121022
	limb grasping	J:137213
Lpin1^fld/Lpin1^fld involves: 129P2/OlaHsd * BALB/cByJ * C57BL/6J	abnormal enzyme/coenzyme activity	J:220917
	abnormal fat pad morphology	J:220917
	decreased body size	J:220917
	decreased liver triglyceride level	J:220917
	decreased triglyceride level	J:220917
	normal homeostasis/metabolism phenotype	J:220917
Lpin1^fld/Lpin1^fld involves: BALB/cByJ	abnormal spermatocyte morphology	J:169933
Lpin1^fld/Lpin1^fld Lpin2^tm1Reue/Lpin2^tm1Reue involves: BALB/cByJ * C57BL/6J	abnormal cardiovascular development	J:189894
	decreased embryo size	J:189894
	embryonic lethality during organogenesis, complete penetrance	J:189894
Lpin1^fld/Lpin1^fld Lpin3^tm1Reue/Lpin3^tm1Reue involves: 129P2/OlaHsd * BALB/cByJ * C57BL/6J	abnormal enzyme/coenzyme activity	J:220917
	abnormal fat pad morphology	J:220917
	decreased body weight	J:220917
	decreased liver triglyceride level	J:220917
	decreased triglyceride level	J:220917
	normal homeostasis/metabolism phenotype	J:220917
Lpin1^fld/Lpin1^fld Nrcam²⁰⁸⁸⁴/Nrcam²⁰⁸⁸⁴ involves: BALB/cByJ * C57BL/6J	forelimb paresis	J:153042
	hindlimb paralysis	J:153042
	postnatal growth retardation	J:153042
	skeletal muscle fiber atrophy	J:153042

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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