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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Fgf23
fibroblast growth factor 23
MGI:1891427
63 phenotypes from 5 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Fgf23em1(IMPC)Ccpcz/Fgf23em1(IMPC)Ccpcz
C57BL/6NCrl-Fgf23em1(IMPC)Ccpcz/Ccpcz 		abnormal anxiety-related response J:211773
abnormal startle reflex J:211773
decreased exploration in new environment J:211773
decreased locomotor activity J:211773
decreased startle reflex J:211773
increased freezing behavior J:211773
Fgf23tm1.1Kew/Fgf23+
B6.129-Fgf23tm1.1Kew 		decreased circulating phosphate level J:180061
increased circulating alkaline phosphatase level J:180061
Fgf23tm1.1Kew/Fgf23tm1.1Kew
B6.129-Fgf23tm1.1Kew 		abnormal compact bone morphology J:180061
abnormal osteoid morphology J:180061
abnormal vitamin D level J:180061
decreased circulating phosphate level J:180061
increased circulating alkaline phosphatase level J:180061
increased osteoid thickness J:180061
osteomalacia J:180061
Fgf23tm1Blan/Fgf23tm1Blan
involves: 129 * C57BL/6 		decreased body size J:173962
increased circulating phosphate level J:173962
premature death J:173962
Fgf23tm1Blan/Fgf23tm1Blan
involves: 129/Sv * C57BL/6 		abnormal bone mineralization J:121006
abnormal bronchus morphology J:121006
decreased body weight J:121006
decreased circulating insulin level J:121006
decreased circulating serum albumin level J:121006
decreased compact bone thickness J:121006
decreased volumetric bone mineral density J:121006
hypoglycemia J:121006
improved glucose tolerance J:121006
increased blood urea nitrogen level J:121006
increased circulating alkaline phosphatase level J:121006
increased circulating calcium level J:121006
increased circulating phosphate level J:121006
small spleen J:121006
thin skin J:121006
Fgf23tm1Blan/Fgf23tm1Blan
Not Specified 		abnormal axial skeleton morphology J:94041
abnormal bone mineralization J:94041
abnormal femur morphology J:94041
abnormal mineral homeostasis J:94041
abnormal rib morphology J:94041
abnormal vertebrae morphology J:94041
decreased body weight J:94041
decreased bone mineral density J:94041
decreased chondrocyte number J:94041
decreased long bone epiphyseal plate size J:94041
decreased volumetric bone mineral density J:94041
fragile skeleton J:94041
increased bone mineral content J:94041
increased circulating alkaline phosphatase level J:94041
increased circulating phosphate level J:94041
postnatal growth retardation J:94041
premature death J:94041
thickened long bone epiphysis J:94041
Fgf23tm1Sliu/Fgf23tm1Sliu
involves: 129S/SvEv * C57BL/6 		abnormal bone mineralization J:110579
abnormal bone structure J:110579
abnormal circulating calcium level J:110579
abnormal circulating phosphate level J:110579
abnormal long bone hypertrophic chondrocyte zone J:110579
abnormal long bone metaphysis morphology J:110579
abnormal long bone morphology J:110579
abnormal trabecular bone morphology J:110579
abnormal vitamin D level J:110579
decreased body length J:110579
decreased body weight J:110579
decreased bone mineral density J:110579
decreased circulating parathyroid hormone level J:110579
premature death J:110579
short femur J:110579
Fgf23tm1Tyam/Fgf23tm1Tyam
involves: C57BL/6 * CBA 		abnormal blood urea nitrogen level J:88172
abnormal kidney morphology J:88172
abnormal renal glomerulus morphology J:88172
abnormal renal phosphate reabsorption J:88172
abnormal reproductive system morphology J:88172
abnormal skeleton development J:88172
abnormal vitamin D level J:88172
decreased body size J:88172
decreased body weight J:88172
decreased bone mineral density J:88172
decreased chondrocyte number J:88172
decreased circulating parathyroid hormone level J:88172
decreased circulating triglyceride level J:88172
decreased lymphocyte cell number J:88172
hypoglycemia J:88172
increased circulating calcium level J:88172
increased circulating cholesterol level J:88172
increased circulating phosphate level J:88172
infertility J:88172
postnatal growth retardation J:88172
premature death J:88172
short femur J:88172
spleen hypoplasia J:88172
thymus atrophy J:88172
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory