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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pcdh15
protocadherin 15
MGI:1891428
90 phenotypes from 20 alleles in 17 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Pcdh15av-2J/Pcdh15av-2J
B6C3Fe a/a-Pcdh15av-2J/J 		abnormal cochlear hair cell morphology J:106625
abnormal cochlear hair cell stereociliary bundle morphology J:106625
abnormal cochlear outer hair cell morphology J:106625
abnormal Hensen cell morphology J:106625
abnormal inner hair cell stereociliary bundle morphology J:106625
abnormal organ of Corti supporting cell morphology J:106625
abnormal orientation of outer hair cell stereociliary bundles J:106625
abnormal outer hair cell stereociliary bundle morphology J:106625
abnormal pillar cell morphology J:106625
abnormal vestibular system physiology J:148677
absent linear vestibular evoked potential J:116914, J:148677
ataxia J:106625
circling J:106625, J:116914
cochlear hair cell degeneration J:106625
normal hearing/vestibular/ear phenotype J:106625
impaired balance J:106625
impaired righting response J:106625
impaired swimming J:106625, J:116914, J:148677
increased or absent threshold for auditory brainstem response J:106625
short cochlear hair cell stereocilia J:106625
Pcdh15av-3J/Pcdh15+
C57BL/6J-Pcdh15av-3J/J 		increased or absent threshold for auditory brainstem response J:183898
Pcdh15av-3J/Pcdh15av-3J
C57BL/6J-Pcdh15av-3J/J 		abnormal circulating lipid level J:320724
abnormal cochlear hair bundle tip links morphology J:135991
abnormal cochlear hair cell inter-stereocilial links morphology J:135991
abnormal cochlear hair cell morphology J:106625
abnormal cochlear outer hair cell morphology J:106625
abnormal inner hair cell kinocilium morphology J:135991
abnormal inner hair cell stereociliary bundle morphology J:106625, J:135991
abnormal orientation of cochlear hair cell stereociliary bundles J:135991
abnormal otolith morphology J:148677
abnormal otolithic membrane morphology J:148677
abnormal outer hair cell kinocilium morphology J:135991
abnormal outer hair cell stereociliary bundle morphology J:106625, J:135991
abnormal reflex J:116914
abnormal vestibular saccule morphology J:148677
abnormal vestibular system physiology J:148677
abnormal vestibuloocular dark reflex J:148677
abnormal vestibuloocular light reflex J:148677
absent linear vestibular evoked potential J:116914, J:148677
circling J:106625, J:116914
decreased circulating cholesterol level J:320724
decreased circulating triglyceride level J:320724
decreased otolith number J:148677
normal hearing/vestibular/ear phenotype J:106625
impaired swimming J:106625, J:116914
increased or absent threshold for auditory brainstem response J:106625
short cochlear hair cell stereocilia J:106625
vestibular hair cell degeneration J:148677
vestibular saccular degeneration J:148677
vestibular saccular macula degeneration J:148677
Pcdh15av-5J/Pcdh15av-5J
C57BL/6J-Pcdh15av-5J/J 		abnormal cochlear hair cell stereociliary bundle morphology J:112247
abnormal cochlear sensory epithelium morphology J:97048
abnormal electroretinogram waveform feature J:112247
abnormal eye electrophysiology J:112247
abnormal inner hair cell stereociliary bundle morphology J:97048
abnormal organ of Corti morphology J:97048
abnormal orientation of cochlear hair cell stereociliary bundles J:112247
abnormal outer hair cell stereociliary bundle morphology J:97048
abnormal rod electrophysiology J:112247
abnormal vestibular hair cell kinocilium morphology J:112247
absent startle reflex J:97048, J:112247
circling J:97048, J:112247
cochlear ganglion degeneration J:78134
cochlear hair cell degeneration J:78134
cochlear outer hair cell degeneration J:97048
deafness J:78134, J:112247
decreased a-wave amplitude J:112247
decreased b-wave amplitude J:112247
head tilt J:78134
head tossing J:78134, J:112247
hyperactivity J:112247
impaired righting response J:97048
impaired swimming J:97048
increased or absent threshold for auditory brainstem response J:97048
organ of Corti degeneration J:97048
postnatal growth retardation J:97048
Pcdh15av-6J/Pcdh15av-6J
B6(129P2)-Pcdh15av-6J 		abnormal cochlear hair cell morphology J:111661
abnormal cochlear sensory epithelium morphology J:111661
abnormal gait J:111661
abnormal orientation of outer hair cell stereociliary bundles J:111661
abnormal outer hair cell stereociliary bundle morphology J:111661
absent startle reflex J:111661
bidirectional circling J:111661
cochlear ganglion hypoplasia J:111661
cochlear inner hair cell degeneration J:111661
cochlear outer hair cell degeneration J:111661
deafness J:111661
decreased body size J:111661
decreased outer hair cell stereocilia number J:111661
head tossing J:111661
normal hearing/vestibular/ear phenotype J:111661
increased or absent threshold for auditory brainstem response J:111661
organ of Corti degeneration J:111661
Pcdh15av-J/Pcdh15av-J
B6.BKS-Pcdh15av-J/J 		abnormal cochlear hair cell morphology J:106625
abnormal cochlear hair cell stereociliary bundle morphology J:106625
abnormal cochlear outer hair cell morphology J:106625
abnormal Hensen cell morphology J:106625
abnormal inner hair cell stereociliary bundle morphology J:106625
abnormal organ of Corti supporting cell morphology J:106625
abnormal orientation of inner hair cell stereociliary bundles J:106625
abnormal pillar cell morphology J:106625
absent linear vestibular evoked potential J:116914
circling J:106625, J:116914
cochlear hair cell degeneration J:106625
normal hearing/vestibular/ear phenotype J:106625
impaired swimming J:106625, J:116914, J:148677
increased or absent threshold for auditory brainstem response J:106625
short cochlear hair cell stereocilia J:106625
Pcdh15av-Jfb/Pcdh15av-Jfb
involves: 129X1/SvJ * C57BL/6 		abnormal cone electrophysiology J:112247
abnormal electroretinogram waveform feature J:112247
abnormal eye electrophysiology J:112247
abnormal rod electrophysiology J:112247
circling J:81272
deafness J:81272
head tossing J:81272
impaired swimming J:81272
Pcdh15av-Tg2742Rpw/Pcdh15av-Tg2742Rpw
FVB/N-Pcdh15av-Tg2742Rpw 		abnormal cochlear hair cell stereociliary bundle morphology J:66738
abnormal inner hair cell stereociliary bundle morphology J:66738
abnormal otolith morphology J:56493, J:148677
abnormal otolithic membrane morphology J:148677
abnormal outer hair cell stereociliary bundle morphology J:66738
abnormal vestibular saccule morphology J:56493, J:148677
absent linear vestibular evoked potential J:148677
circling J:56493
deafness J:56493
decreased otolith number J:148677
enlarged otoliths J:56493
normal hearing/vestibular/ear phenotype J:56493
normal homeostasis/metabolism phenotype J:320724
impaired swimming J:56493
increased or absent threshold for auditory brainstem response J:56493
organ of Corti degeneration J:56493
vestibular hair cell degeneration J:148677
vestibular saccular degeneration J:148677
vestibular saccular macula degeneration J:148677
Pcdh15av/Pcdh15av
involves: K 		abnormal cochlear ganglion morphology J:5225
abnormal cochlear hair cell morphology J:5225
abnormal maternal nurturing J:5225
abnormal organ of Corti morphology J:5225
absent tunnel of Corti J:5225
deafness J:5225
no abnormal phenotype detected J:5225
Pcdh15em1(IMPC)Wtsi/Pcdh15em1(IMPC)Wtsi
C57BL/6N-Pcdh15em1(IMPC)Wtsi/Wtsi 		increased bone mineral content J:211773
Pcdh15em1Zma/Pcdh15em1Zma
involves: C57BL/6J 		abnormal cone electrophysiology J:342718
abnormal hair cell mechanoelectric transduction J:342718
abnormal homeostasis J:342718
abnormal motor coordination/balance J:342718
abnormal rod electrophysiology J:342718
areflexia J:342718
circling J:342718
cochlear hair cell degeneration J:342718
deafness J:342718
head bobbing J:342718
hyperactivity J:342718
thin retina outer nuclear layer J:342718
normal vision/eye phenotype J:342718
Pcdh15m1Btlr/Pcdh15m1Btlr
C57BL/6J-Pcdh15m1Btlr 		circling J:140625
hyperactivity J:140625
Pcdh15m2Btlr/Pcdh15m2Btlr
involves: C57BL/6J 		dystonia J:198553
hyperactivity J:198553
retropulsion J:198553
Pcdh15m3Btlr/Pcdh15m3Btlr
C57BL/6J-Pcdh15m3Btlr 		circling J:203622
head bobbing J:203622
hyperactivity J:203622
impaired coordination J:203622
Pcdh15m4Btlr/Pcdh15m4Btlr
C57BL/6J-Pcdh15m4Btlr 		circling J:236676
head tilt J:236676
Pcdh15m5Btlr/Pcdh15m5Btlr
C57BL/6J-Pcdh15m5Btlr 		ataxia J:255213
circling J:255213
hyperactivity J:255213
Pcdh15roda/Pcdh15roda
BALB/c-Pcdh15roda 		abnormal cochlear hair cell stereociliary bundle morphology J:220658
abnormal inner hair cell kinocilium location or orientation J:220658
circling J:227974
cochlear hair cell degeneration J:220658
deafness J:220658, J:227974
decreased inner hair cell stereocilia number J:220658
fused inner hair cell stereocilia J:220658
head bobbing J:227974
impaired balance J:220658
Pcdh15tm1.1Mll/Pcdh15tm1.1Mll
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * SJL 		normal hearing/vestibular/ear phenotype J:171627
Pcdh15tm1.1Ugds/Pcdh15tm1.1Ugds
Myo15atm1.1(cre)Ugds/Myo15a+
involves: 129S1/SvImJ * C57BL/6J 		abnormal auditory brainstem response J:209275
abnormal cochlear hair bundle tip links morphology J:209275
abnormal cochlear nerve compound action potential J:209275
abnormal hair cell mechanoelectric transduction J:209275
abnormal outer hair cell stereociliary bundle morphology J:209275
deafness J:209275
decreased inner hair cell stereocilia number J:209275
decreased outer hair cell stereocilia number J:209275
increased or absent threshold for auditory brainstem response J:209275
short inner hair cell stereocilia J:209275
short outer hair cell stereocilia J:209275
Pcdh15tm2.1Mll/Pcdh15tm2.1Mll
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * SJL 		abnormal inner hair cell kinocilium location or orientation J:171627
abnormal orientation of outer hair cell stereociliary bundles J:171627
abnormal outer hair cell kinocilium location or orientation J:171627
abnormal vestibular hair cell kinocilium morphology J:171627
absent distortion product otoacoustic emissions J:171627
normal behavior/neurological phenotype J:171627
cochlear hair cell degeneration J:171627
cochlear outer hair cell degeneration J:171627
deafness J:171627
decreased outer hair cell stereocilia number J:171627
increased or absent threshold for auditory brainstem response J:171627
Pcdh15tm3.1Mll/Pcdh15tm3.1Mll
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * SJL 		normal hearing/vestibular/ear phenotype J:171627
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory