Sppl3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sppl3
signal peptide peptidase 3
MGI:1891433

28 phenotypes from 4 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sppl3^em1(IMPC)Bay/Sppl3⁺ C57BL/6N-Sppl3^em1(IMPC)Bay/BayMmucd	decreased locomotor activity	J:211773
	prolonged RR interval	J:211773
Sppl3^em1(IMPC)Bay/Sppl3^em1(IMPC)Bay C57BL/6N-Sppl3^em1(IMPC)Bay/BayMmucd	abnormal body wall morphology	J:211773
	abnormal embryo size	J:211773
	abnormal facial morphology	J:211773
	microphthalmia	J:211773
	preweaning lethality, complete penetrance	J:211773
Sppl3^em1Pomz/Sppl3^em1Pomz C57BL/6J-Sppl3^em1Pomz	neonatal lethality, incomplete penetrance	J:280182
Sppl3^em1Pomz/Sppl3^em1Pomz C57BL/6J-Sppl3^em1Pomz	postnatal lethality, complete penetrance	J:280182
Sppl3^{Gt(OST279815)Lex}/Sppl3^{Gt(OST279815)Lex} involves: 129S5/SvEvBrd * C57BL/6J	abnormal depression-related behavior	J:161922
	decreased body length	J:161922
	decreased body weight	J:161922
	decreased exploration in new environment	J:161922
	decreased lean body mass	J:161922
	increased anxiety-related response	J:161922
	postnatal growth retardation	J:161922
	reduced fertility	J:161922
Sppl3^tm1Itl/Sppl3^em1Pomz Ncr1^{tm1.1(icre)Viv}/Ncr1⁺ involves: 129S/SvEv * C57BL/6 * C57BL/6J	abnormal NK cell differentiation	J:280182
	decreased mature NK cell number	J:280182
	decreased NK cell number	J:280182
	increased immature NK cell number	J:280182
	normal mortality/aging	J:280182
Sppl3^tm1Itl/Sppl3^tm1Itl Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ involves: 129S/SvEv * C57BL/6 * C57BL/10 * CBA/Ca	abnormal NK cell differentiation	J:280182
	decreased mature NK cell number	J:280182
	decreased NK cell number	J:280182
	normal hematopoietic system phenotype	J:280182
	normal immune system phenotype	J:280182
	impaired natural killer cell mediated cytotoxicity	J:280182
	increased immature NK cell number	J:280182
	normal mortality/aging	J:280182
Sppl3^tm1Itl/Sppl3^tm1Itl Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ involves: 129S/SvEv * C57BL/6 * CBA	decreased birth body size	J:280182
	neonatal lethality, incomplete penetrance	J:280182
	postnatal lethality, incomplete penetrance	J:280182
Sppl3^tm1Itl/Sppl3^tm1Itl Ncr1^{tm1.1(icre)Viv}/Ncr1⁺ involves: 129S/SvEv * C57BL/6	abnormal NK cell differentiation	J:280182
	abnormal NK cell physiology	J:280182
	decreased mature NK cell number	J:280182
	decreased NK cell number	J:280182
	impaired natural killer cell mediated cytotoxicity	J:280182
	increased immature NK cell number	J:280182

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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