About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Foxp3
forkhead box P3
MGI:1891436
156 phenotypes from 17 alleles in 20 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Foxp3m1Btlr/Y
C57BL/6J-Foxp3m1Btlr 		abnormal reproductive system development J:141212
alopecia J:141212
azoospermia J:141212
decreased body size J:141212
dry skin J:141212
premature death J:141212
scaly skin J:141212
skin lesions J:141212
Foxp3m1Btlr/Foxp3+
C57BL/6J-Foxp3m1Btlr 		no abnormal phenotype detected J:141212
Foxp3m1Btlr/Foxp3m1Btlr
C57BL/6J-Foxp3m1Btlr 		normal mortality/aging J:141212
Foxp3sf/Y
B6.Cg-Foxp3sf 		abnormal CD4-positive, alpha beta T cell morphology J:82560
abnormal CD4-positive, alpha-beta T cell physiology J:82560
abnormal homeostasis J:167802
abnormal megakaryocyte progenitor cell morphology J:167802
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number J:82560
decreased megakaryocyte cell number J:167802
increased mean platelet volume J:167802
thrombocytopenia J:167802
Foxp3sf/Y
B6.Cg-Foxp3sf/J 		lung inflammation J:125129
salivary gland inflammation J:125129
skin inflammation J:125129
Foxp3sf/Y
either: 129Rl.Cg-Foxp3sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR) 		abnormal atrial thrombosis J:11262
abnormal B cell physiology J:11262
abnormal epidermal layer morphology J:11262
abnormal erythrocyte morphology J:11262
abnormal hepatic cord morphology J:11262
abnormal liver morphology J:11262
abnormal lymph node B cell domain morphology J:11262
abnormal lymph node medullary cord morphology J:11262
abnormal lymph node morphology J:11262
abnormal lymph node T cell domain morphology J:11262
abnormal lymphocyte morphology J:11262
abnormal macrophage morphology J:11262
abnormal male reproductive system morphology J:11262
abnormal spleen morphology J:11262
abnormal spleen white pulp morphology J:11262
abnormal tail ring morphology J:11262
abnormal thymus cortex morphology J:11262
abnormal thymus morphology J:11262
absent spleen marginal zone J:11262
anemia J:11262
anisocytosis J:11262
blepharitis J:11262
cachexia J:11262
cryptorchism J:11262
decreased body size J:11262
decreased hematocrit J:11262
decreased hemoglobin content J:11262
decreased spleen B cell follicle number J:11262
dermatitis J:11262
dilated liver sinusoidal space J:11262
distended abdomen J:11262
enlarged heart J:11262
enlarged liver J:11262
enlarged lymph nodes J:11262
epidermal hyperplasia J:11262
extramedullary hematopoiesis J:11262
hemosiderosis J:11262
hunched posture J:11262
increased IgG level J:11262
increased IgM level J:11262
increased inflammatory response J:11262
increased leukocyte cell number J:11262
increased mean corpuscular volume J:11262
increased spleen red pulp amount J:11262
increased spleen weight J:11262
jaundice J:11262
liver inflammation J:11262
multifocal hepatic necrosis J:11262
orthokeratosis J:11262
pale kidney J:11262
parakeratosis J:11262
pleural effusion J:11262
poikilocytosis J:11262
polychromatophilia J:11262
premature death J:11262
scaly ears J:11262
scaly skin J:11262
skin lesions J:11262
small ears J:11262
small testis J:11262
small thymus J:11262
thick ears J:11262
Foxp3sf/Y
involves: 101/H * C3H/HeH * STOCK MR 		abnormal breathing pattern J:10398
abnormal erythrocyte morphology J:10398
abnormal liver morphology J:10398
abnormal male reproductive system morphology J:10398
abnormal reticulocyte morphology J:10398
abnormal spleen morphology J:10398
absent scrotum J:10398
anemia J:10398
conjunctivitis J:10398
cryptorchism J:10398
decreased body size J:10398
decreased body weight J:10398
decreased erythrocyte cell number J:10398
decreased hematocrit J:10398
decreased hemoglobin content J:10398
decreased megakaryocyte cell number J:10398
diarrhea J:10398
enlarged liver J:10398
extramedullary hematopoiesis J:10398
gastrointestinal hemorrhage J:10398
increased leukocyte cell number J:10398
increased spleen red pulp amount J:10398
increased spleen weight J:10398
increased spleen white pulp amount J:10398
intermingled spleen red and white pulp J:10398
lethality at weaning, complete penetrance J:10398
lethargy J:10398
melena J:10398
narrow eye opening J:10398
pale kidney J:10398
pale liver J:10398
postnatal growth retardation J:10398
scaly skin J:10398
short perineum J:10398
small ears J:10398
small gonad J:10398
thrombocytopenia J:10398
tight skin J:10398
Foxp3sf/0
involves: STOCK MR 		delayed eyelid opening J:13126
postnatal lethality J:13126
scaly skin J:13126
tight skin J:13126
Foxp3sf/Y
involves: STOCK MR 		abnormal male reproductive system morphology J:13126
absent prostate gland anterior lobe J:14076
absent scrotum J:14076
absent seminal vesicle J:14076
cryptorchism J:14076
decreased body size J:13126
delayed eyelid opening J:13126
male infertility J:13126, J:14076
postnatal lethality J:13126
premature death J:13126
scaly skin J:13126, J:14076
small gonad J:14076
small testis J:14076
tight skin J:13126
Foxp3sf/?
Not Specified 		liver inflammation J:138808
lung inflammation J:138808
Foxp3sf/Foxp3sf
Tg(Rorc-EGFP)1Ebe/?
involves: C57BL/6 		abnormal effector T cell morphology J:137020
Foxp3tm1(CD2/CD52)Shori/Foxp3tm1(CD2/CD52)Shori
involves: C57BL/6 		decreased regulatory T cell number J:171378
increased susceptibility to type IV hypersensitivity reaction J:171378
Foxp3tm1(cre)Saka/Y
involves: BALB/c 		increased autoantibody level J:140085
stomach inflammation J:140085
Foxp3tm1.1Ayr/Y
involves: 129S1/Sv * 129X1/SvJ 		abnormal CD4-positive, alpha beta T cell morphology J:82560
abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology J:82560
decreased body size J:82560
enlarged lymph nodes J:82560
enlarged spleen J:82560
increased susceptibility to autoimmune disorder J:82560
scaly ears J:82560
scaly skin J:82560
skin inflammation J:82560
Foxp3tm1.1Ayr/Y
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		dermatitis J:117743
enlarged spleen J:117743
increased susceptibility to autoimmune disorder J:117743
liver inflammation J:117743
lung inflammation J:117743
lymph node inflammation J:117743
scaly skin J:117743
Foxp3tm1.1Ayr/Foxp3tm1.1Ayr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal T cell differentiation J:125405
decreased double-positive T cell number J:125405
dermatitis J:117743
enlarged spleen J:117743
increased susceptibility to autoimmune disorder J:117743
liver inflammation J:117743
lung inflammation J:117743
lymph node inflammation J:117743
scaly skin J:117743
thymus hypoplasia J:125405
Foxp3tm1Ayr/Foxp3tm1Ayr
involves: 129S1/Sv * 129X1/SvJ 		no abnormal phenotype detected J:82560
Foxp3tm1Ayr/Foxp3tm1Ayr
Foxn1tm3(cre)Nrm/Foxn1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal immune system phenotype J:125405
Foxp3tm1Ayr/Foxp3tm1Ayr
Tg(Cd4-cre)1Cwi/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 		abnormal T cell differentiation J:125405
decreased double-positive T cell number J:125405
thymus hypoplasia J:125405
Foxp3tm1Ayr/Y
Tg(Cd4-cre)1Cwi/0
involves: C57BL/6 * DBA/2 		decreased body size J:97029
dermatitis J:97029
enlarged lymph nodes J:97029
enlarged spleen J:97029
increased susceptibility to autoimmune disorder J:97029
Foxp3tm1Flv/Foxp3+
involves: C57BL/6 		no abnormal phenotype detected J:97415
Foxp3tm1Tch/Y
B6.129X1-Foxp3tm1Tch 		abnormal inflammatory response J:117165
anemia J:117165
dermatitis J:117165
increased eosinophil cell number J:117165
increased IgE level J:117165
increased leukocyte cell number J:117165
increased lymphocyte cell number J:117165
increased monocyte cell number J:117165
postnatal lethality, complete penetrance J:117165
respiratory system inflammation J:117165
thrombocytopenia J:117165
Foxp3tm1Tch/Foxp3+
C.129X1-Foxp3tm1Tch 		no abnormal phenotype detected J:117165
Foxp3tm1Tch/Y
C.129X1-Foxp3tm1Tch 		abnormal chemokine level J:117165
abnormal cytokine secretion J:117165
abnormal inflammatory response J:117165
abnormal lymphocyte physiology J:117165
abnormal respiratory mucosa goblet cell morphology J:117165
absent regulatory T cells J:117165
anemia J:117165
crypts of Lieberkuhn abscesses J:117165
dermatitis J:117165
enlarged spleen J:117165
increased activated T cell number J:117165
increased CD4-positive, alpha-beta T cell number J:117165
increased CD8-positive, alpha-beta T cell number J:117165
increased circulating interferon-gamma level J:117165
increased circulating interleukin-4 level J:117165
increased circulating interleukin-5 level J:117165
increased circulating interleukin-6 level J:117165
increased circulating interleukin-10 level J:117165
increased circulating tumor necrosis factor level J:117165
increased eosinophil cell number J:117165
increased IgE level J:117165
increased IgG1 level J:117165
increased leukocyte cell number J:117165
increased lymphocyte cell number J:117165
increased monocyte cell number J:117165
postnatal lethality, complete penetrance J:117165, J:120636
respiratory system inflammation J:117165
thrombocytopenia J:117165
Foxp3tm2.1(EGFP/cre)Shori/Y
involves: 129 * C57BL/6 		decreased regulatory T cell number J:234397
Foxp3tm2Ayr/Y
involves: 129S1/Sv * 129X1/SvJ 		normal immune system phenotype J:97029
no abnormal phenotype detected J:97029
Foxp3tm2Ayr/Foxp3tm2Ayr
involves: 129S1/Sv * 129X1/SvJ 		normal immune system phenotype J:97029
no abnormal phenotype detected J:97029
Foxp3tm2Flv/Foxp3+
involves: C57BL/6 		no abnormal phenotype detected J:118631
Foxp3tm2Flv/Y
involves: C57BL/6 		abnormal CD4-positive, alpha-beta T cell physiology J:118631
abnormal CD8-positive, alpha-beta T cell physiology J:118631
abnormal immune system physiology J:118631
blepharitis J:118631
decreased body size J:118631
enlarged lymph nodes J:118631
enlarged spleen J:118631
increased autoantibody level J:118631
male infertility J:118631
premature death J:118631
scaly skin J:118631
Foxp3tm2Tch/Foxp3+
C.129X1-Foxp3tm2Tch 		normal immune system phenotype J:120713
Foxp3tm2Tch/Y
C.129X1-Foxp3tm2Tch 		normal immune system phenotype J:120713
Foxp3tm3Tch/Y
C.129X1-Foxp3tm3Tch 		abnormal CD4-positive, alpha beta T cell morphology J:120636
abnormal CD4-positive, alpha-beta T cell physiology J:120636
abnormal cytokine secretion J:120636
abnormal immune system organ morphology J:120636
abnormal lymphocyte physiology J:120636
abnormal regulatory T cell physiology J:120636
abnormal T cell subpopulation ratio J:120636
colitis J:120636
enlarged lymph nodes J:120636
enlarged spleen J:120636
increased T cell proliferation J:120636
postnatal lethality, complete penetrance J:120636
thymus hypoplasia J:120636
Foxp3tm3Tch/Foxp3+
C.129X1-Foxp3tm3Tch 		abnormal CD4-positive, alpha-beta T cell physiology J:120636
decreased T cell number J:120636
decreased thymocyte number J:120636
increased T cell apoptosis J:120636
normal mortality/aging J:120636
Foxp3tm5.2Ayr/Foxp3tm5.2Ayr
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ 		abnormal gut-associated lymphoid tissue morphology J:156942
abnormal intraepithelial T cell morphology J:156942
abnormal mesenteric lymph node morphology J:156942
abnormal Peyer's patch morphology J:156942
abnormal T cell differentiation J:156942
decreased regulatory T cell number J:156942
increased T cell number J:156942
Foxp3tm6.2Ayr/Foxp3tm6.2Ayr
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ 		decreased regulatory T cell number J:156942
Foxp3tm7.2Ayr/Foxp3+
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ 		decreased regulatory T cell number J:156942
Foxp3tm7.2Ayr/Foxp3tm7.2Ayr
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ 		abnormal regulatory T cell morphology J:156942
decreased regulatory T cell number J:156942
Foxp3tm8Ayr/Foxp3+
B6.129-Foxp3tm8Ayr 		no abnormal phenotype detected J:157377
Foxp3tm8Ayr/Y
B6.129-Foxp3tm8Ayr 		autoimmune response J:157377
premature death J:157377
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory