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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Foxp3
forkhead box P3
MGI:1891436
156 phenotypes from 17 alleles in 20 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Foxp3m1Btlr/Y
C57BL/6J-Foxp3m1Btlr 		abnormal reproductive system development J:141212
alopecia J:141212
azoospermia J:141212
decreased body size J:141212
dry skin J:141212
premature death J:141212
scaly skin J:141212
skin lesions J:141212
Foxp3m1Btlr/Foxp3+
C57BL/6J-Foxp3m1Btlr 		no abnormal phenotype detected J:141212
Foxp3m1Btlr/Foxp3m1Btlr
C57BL/6J-Foxp3m1Btlr 		normal mortality/aging J:141212
Foxp3sf/Y
B6.Cg-Foxp3sf 		abnormal CD4-positive, alpha beta T cell morphology J:82560
abnormal CD4-positive, alpha-beta T cell physiology J:82560
abnormal homeostasis J:167802
abnormal megakaryocyte progenitor cell morphology J:167802
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number J:82560
decreased megakaryocyte cell number J:167802
increased mean platelet volume J:167802
thrombocytopenia J:167802
Foxp3sf/Y
B6.Cg-Foxp3sf/J 		lung inflammation J:125129
salivary gland inflammation J:125129
skin inflammation J:125129
Foxp3sf/Y
either: 129Rl.Cg-Foxp3sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR) 		abnormal atrial thrombosis J:11262
abnormal B cell physiology J:11262
abnormal epidermal layer morphology J:11262
abnormal erythrocyte morphology J:11262
abnormal hepatic cord morphology J:11262
abnormal liver morphology J:11262
abnormal lymph node B cell domain morphology J:11262
abnormal lymph node medullary cord morphology J:11262
abnormal lymph node morphology J:11262
abnormal lymph node T cell domain morphology J:11262
abnormal lymphocyte morphology J:11262
abnormal macrophage morphology J:11262
abnormal male reproductive system morphology J:11262
abnormal spleen morphology J:11262
abnormal spleen white pulp morphology J:11262
abnormal tail ring morphology J:11262
abnormal thymus cortex morphology J:11262
abnormal thymus morphology J:11262
absent spleen marginal zone J:11262
anemia J:11262
anisocytosis J:11262
blepharitis J:11262
cachexia J:11262
cryptorchism J:11262
decreased body size J:11262
decreased hematocrit J:11262
decreased hemoglobin content J:11262
decreased spleen B cell follicle number J:11262
dermatitis J:11262
dilated liver sinusoidal space J:11262
distended abdomen J:11262
enlarged heart J:11262
enlarged liver J:11262
enlarged lymph nodes J:11262
epidermal hyperplasia J:11262
extramedullary hematopoiesis J:11262
hemosiderosis J:11262
hunched posture J:11262
increased IgG level J:11262
increased IgM level J:11262
increased inflammatory response J:11262
increased leukocyte cell number J:11262
increased mean corpuscular volume J:11262
increased spleen red pulp amount J:11262
increased spleen weight J:11262
jaundice J:11262
liver inflammation J:11262
multifocal hepatic necrosis J:11262
orthokeratosis J:11262
pale kidney J:11262
parakeratosis J:11262
pleural effusion J:11262
poikilocytosis J:11262
polychromatophilia J:11262
premature death J:11262
scaly ears J:11262
scaly skin J:11262
skin lesions J:11262
small ears J:11262
small testis J:11262
small thymus J:11262
thick ears J:11262
Foxp3sf/Y
involves: 101/H * C3H/HeH * STOCK MR 		abnormal breathing pattern J:10398
abnormal erythrocyte morphology J:10398
abnormal liver morphology J:10398
abnormal male reproductive system morphology J:10398
abnormal reticulocyte morphology J:10398
abnormal spleen morphology J:10398
absent scrotum J:10398
anemia J:10398
conjunctivitis J:10398
cryptorchism J:10398
decreased body size J:10398
decreased body weight J:10398
decreased erythrocyte cell number J:10398
decreased hematocrit J:10398
decreased hemoglobin content J:10398
decreased megakaryocyte cell number J:10398
diarrhea J:10398
enlarged liver J:10398
extramedullary hematopoiesis J:10398
gastrointestinal hemorrhage J:10398
increased leukocyte cell number J:10398
increased spleen red pulp amount J:10398
increased spleen weight J:10398
increased spleen white pulp amount J:10398
intermingled spleen red and white pulp J:10398
lethality at weaning, complete penetrance J:10398
lethargy J:10398
melena J:10398
narrow eye opening J:10398
pale kidney J:10398
pale liver J:10398
postnatal growth retardation J:10398
scaly skin J:10398
short perineum J:10398
small ears J:10398
small gonad J:10398
thrombocytopenia J:10398
tight skin J:10398
Foxp3sf/0
involves: STOCK MR 		delayed eyelid opening J:13126
postnatal lethality J:13126
scaly skin J:13126
tight skin J:13126
Foxp3sf/Y
involves: STOCK MR 		abnormal male reproductive system morphology J:13126
absent prostate gland anterior lobe J:14076
absent scrotum J:14076
absent seminal vesicle J:14076
cryptorchism J:14076
decreased body size J:13126
delayed eyelid opening J:13126
male infertility J:13126, J:14076
postnatal lethality J:13126
premature death J:13126
scaly skin J:13126, J:14076
small gonad J:14076
small testis J:14076
tight skin J:13126
Foxp3sf/?
Not Specified 		liver inflammation J:138808
lung inflammation J:138808
Foxp3sf/Foxp3sf
Tg(Rorc-EGFP)1Ebe/?
involves: C57BL/6 		abnormal effector T cell morphology J:137020
Foxp3tm1(CD2/CD52)Shori/Foxp3tm1(CD2/CD52)Shori
involves: C57BL/6 		decreased regulatory T cell number J:171378
increased susceptibility to type IV hypersensitivity reaction J:171378
Foxp3tm1(cre)Saka/Y
involves: BALB/c 		increased autoantibody level J:140085
stomach inflammation J:140085
Foxp3tm1.1Ayr/Y
involves: 129S1/Sv * 129X1/SvJ 		abnormal CD4-positive, alpha beta T cell morphology J:82560
abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology J:82560
decreased body size J:82560
enlarged lymph nodes J:82560
enlarged spleen J:82560
increased susceptibility to autoimmune disorder J:82560
scaly ears J:82560
scaly skin J:82560
skin inflammation J:82560
Foxp3tm1.1Ayr/Y
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		dermatitis J:117743
enlarged spleen J:117743
increased susceptibility to autoimmune disorder J:117743
liver inflammation J:117743
lung inflammation J:117743
lymph node inflammation J:117743
scaly skin J:117743
Foxp3tm1.1Ayr/Foxp3tm1.1Ayr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal T cell differentiation J:125405
decreased double-positive T cell number J:125405
dermatitis J:117743
enlarged spleen J:117743
increased susceptibility to autoimmune disorder J:117743
liver inflammation J:117743
lung inflammation J:117743
lymph node inflammation J:117743
scaly skin J:117743
thymus hypoplasia J:125405
Foxp3tm1Ayr/Foxp3tm1Ayr
involves: 129S1/Sv * 129X1/SvJ 		no abnormal phenotype detected J:82560
Foxp3tm1Ayr/Foxp3tm1Ayr
Foxn1tm3(cre)Nrm/Foxn1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal immune system phenotype J:125405
Foxp3tm1Ayr/Foxp3tm1Ayr
Tg(Cd4-cre)1Cwi/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 		abnormal T cell differentiation J:125405
decreased double-positive T cell number J:125405
thymus hypoplasia J:125405
Foxp3tm1Ayr/Y
Tg(Cd4-cre)1Cwi/0
involves: C57BL/6 * DBA/2 		decreased body size J:97029
dermatitis J:97029
enlarged lymph nodes J:97029
enlarged spleen J:97029
increased susceptibility to autoimmune disorder J:97029
Foxp3tm1Flv/Foxp3+
involves: C57BL/6 		no abnormal phenotype detected J:97415
Foxp3tm1Tch/Y
B6.129X1-Foxp3tm1Tch 		abnormal inflammatory response J:117165
anemia J:117165
dermatitis J:117165
increased eosinophil cell number J:117165
increased IgE level J:117165
increased leukocyte cell number J:117165
increased lymphocyte cell number J:117165
increased monocyte cell number J:117165
postnatal lethality, complete penetrance J:117165
respiratory system inflammation J:117165
thrombocytopenia J:117165
Foxp3tm1Tch/Foxp3+
C.129X1-Foxp3tm1Tch 		no abnormal phenotype detected J:117165
Foxp3tm1Tch/Y
C.129X1-Foxp3tm1Tch 		abnormal chemokine level J:117165
abnormal cytokine secretion J:117165
abnormal inflammatory response J:117165
abnormal lymphocyte physiology J:117165
abnormal respiratory mucosa goblet cell morphology J:117165
absent regulatory T cells J:117165
anemia J:117165
crypts of Lieberkuhn abscesses J:117165
dermatitis J:117165
enlarged spleen J:117165
increased activated T cell number J:117165
increased CD4-positive, alpha-beta T cell number J:117165
increased CD8-positive, alpha-beta T cell number J:117165
increased circulating interferon-gamma level J:117165
increased circulating interleukin-4 level J:117165
increased circulating interleukin-5 level J:117165
increased circulating interleukin-6 level J:117165
increased circulating interleukin-10 level J:117165
increased circulating tumor necrosis factor level J:117165
increased eosinophil cell number J:117165
increased IgE level J:117165
increased IgG1 level J:117165
increased leukocyte cell number J:117165
increased lymphocyte cell number J:117165
increased monocyte cell number J:117165
postnatal lethality, complete penetrance J:117165, J:120636
respiratory system inflammation J:117165
thrombocytopenia J:117165
Foxp3tm2.1(EGFP/cre)Shori/Y
involves: 129 * C57BL/6 		decreased regulatory T cell number J:234397
Foxp3tm2Ayr/Y
involves: 129S1/Sv * 129X1/SvJ 		normal immune system phenotype J:97029
no abnormal phenotype detected J:97029
Foxp3tm2Ayr/Foxp3tm2Ayr
involves: 129S1/Sv * 129X1/SvJ 		normal immune system phenotype J:97029
no abnormal phenotype detected J:97029
Foxp3tm2Flv/Foxp3+
involves: C57BL/6 		no abnormal phenotype detected J:118631
Foxp3tm2Flv/Y
involves: C57BL/6 		abnormal CD4-positive, alpha-beta T cell physiology J:118631
abnormal CD8-positive, alpha-beta T cell physiology J:118631
abnormal immune system physiology J:118631
blepharitis J:118631
decreased body size J:118631
enlarged lymph nodes J:118631
enlarged spleen J:118631
increased autoantibody level J:118631
male infertility J:118631
premature death J:118631
scaly skin J:118631
Foxp3tm2Tch/Foxp3+
C.129X1-Foxp3tm2Tch 		normal immune system phenotype J:120713
Foxp3tm2Tch/Y
C.129X1-Foxp3tm2Tch 		normal immune system phenotype J:120713
Foxp3tm3Tch/Y
C.129X1-Foxp3tm3Tch 		abnormal CD4-positive, alpha beta T cell morphology J:120636
abnormal CD4-positive, alpha-beta T cell physiology J:120636
abnormal cytokine secretion J:120636
abnormal immune system organ morphology J:120636
abnormal lymphocyte physiology J:120636
abnormal regulatory T cell physiology J:120636
abnormal T cell subpopulation ratio J:120636
colitis J:120636
enlarged lymph nodes J:120636
enlarged spleen J:120636
increased T cell proliferation J:120636
postnatal lethality, complete penetrance J:120636
thymus hypoplasia J:120636
Foxp3tm3Tch/Foxp3+
C.129X1-Foxp3tm3Tch 		abnormal CD4-positive, alpha-beta T cell physiology J:120636
decreased T cell number J:120636
decreased thymocyte number J:120636
increased T cell apoptosis J:120636
normal mortality/aging J:120636
Foxp3tm5.2Ayr/Foxp3tm5.2Ayr
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ 		abnormal gut-associated lymphoid tissue morphology J:156942
abnormal intraepithelial T cell morphology J:156942
abnormal mesenteric lymph node morphology J:156942
abnormal Peyer's patch morphology J:156942
abnormal T cell differentiation J:156942
decreased regulatory T cell number J:156942
increased T cell number J:156942
Foxp3tm6.2Ayr/Foxp3tm6.2Ayr
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ 		decreased regulatory T cell number J:156942
Foxp3tm7.2Ayr/Foxp3+
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ 		decreased regulatory T cell number J:156942
Foxp3tm7.2Ayr/Foxp3tm7.2Ayr
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ 		abnormal regulatory T cell morphology J:156942
decreased regulatory T cell number J:156942
Foxp3tm8Ayr/Foxp3+
B6.129-Foxp3tm8Ayr 		no abnormal phenotype detected J:157377
Foxp3tm8Ayr/Y
B6.129-Foxp3tm8Ayr 		autoimmune response J:157377
premature death J:157377
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/05/2024
MGI 6.24 		The Jackson Laboratory