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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Foxp3
forkhead box P3
MGI:1891436
162 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Altretm1.1Hbgl/Altretm1.1Hbgl
Foxp3tm4(YFP/icre)Ayr/Y
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal liver morphology J:342907
abnormal mitochondrial morphology J:342907
abnormal mitochondrial physiology J:342907
abnormal regulatory T cell physiology J:342907
decreased mitochondrial size J:342907
decreased regulatory T cell number J:342907
decreased T cell number J:342907
increased CD8-positive, alpha-beta T cell number J:342907
increased circulating alanine transaminase level J:342907
increased interleukin-17 secretion J:342907
increased liver tumor incidence J:342907
increased memory T cell number J:342907
increased regulatory T cell apoptosis J:342907
increased susceptibility to diet-induced hepatic steatosis J:342907
liver fibrosis J:342907
premature death J:342907
Aregtm2c(EUCOMM)Hmgu/Aregtm2c(EUCOMM)Hmgu
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N 		decreased blood oxygen saturation level J:224904
decreased body surface temperature J:224904
normal immune system phenotype J:224904
increased susceptibility to Orthomyxoviridae infection J:224904
normal mortality/aging J:224904
B2mtm1Jae/B2mtm1Jae
Foxp3sfOtcspf/Y
involves: 129/Rl * 129S2/SvPas 		abnormal immune system organ morphology J:20865
abnormal interleukin level J:20865
abnormal lymph node morphology J:20865
abnormal tumor necrosis factor level J:20865
anemia J:20865
decreased body size J:20865
decreased hematocrit J:20865
dermatitis J:20865
enlarged lymph nodes J:20865
enlarged spleen J:20865
increased CD4-positive, alpha-beta T cell number J:20865
increased IgG level J:20865
increased IgM level J:20865
increased immunoglobulin level J:20865
increased plasma cell number J:20865
B9d2/Tgfb1tm1Flv/B9d2+
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ 		normal growth/size/body region phenotype J:169839
normal immune system phenotype J:169839
increased regulatory T cell number J:169839
B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ 		normal growth/size/body region phenotype J:169839
normal immune system phenotype J:169839
increased regulatory T cell number J:169839
Bcl2l11tm6.1Boui/Bcl2l11tm6.1Boui
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		increased regulatory T cell number J:208318
Becn1tm1Smoc/Becn1tm1Smoc
Foxp3tm4(YFP/icre)Ayr/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal regulatory T cell physiology J:306129
Becn1tm1Smoc/Becn1tm1Smoc
Zfp91tm1Smoc/Zfp91tm1Smoc
Foxp3tm4(YFP/icre)Ayr/Y
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal regulatory T cell physiology J:306129
Cd4tm1Litt/Cd4tm1Litt
Foxp3sfOtcspf/Y
involves: 129/Rl * 129S2/SvPas 		abnormal CD8-positive, alpha beta T cell morphology J:20865
abnormal cytokine secretion J:20865
abnormal immune system organ morphology J:20865
enlarged lymph nodes J:20865
increased IgG level J:20865
increased IgM level J:20865
increased interleukin-4 secretion J:20865
increased interleukin-6 secretion J:20865
increased tumor necrosis factor secretion J:20865
premature death J:20865
Cd28tm1Ltu/Cd28tm1Ltu
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal eyelid morphology J:194503
decreased locomotor activity J:194503
decreased regulatory T cell number J:194503
decreased T cell proliferation J:194503
enlarged lymph nodes J:194503
enlarged spleen J:194503
focal hair loss J:194503
hunched posture J:194503
increased activated T cell number J:194503
increased B cell number J:194503
increased susceptibility to autoimmune disorder J:194503
increased susceptibility to experimental autoimmune encephalomyelitis J:194503
ruffled hair J:194503
skin inflammation J:194503
skin lesions J:194503
Cishtm1.1Cdon/Cishtm1.1Cdon
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S/Sv * 129X1/SvJ * C57BL/6 		normal immune system phenotype J:204829
Ctla4tm1Saka/Ctla4tm1Saka
Foxp3tm1(cre)Saka/Y
involves: BALB/c 		abnormal immunoglobulin level J:140085
abnormal liver morphology J:140085
abnormal regulatory T cell physiology J:140085
abnormal splenic cell ratio J:140085
enlarged heart J:140085
increased autoantibody level J:140085
increased IgE level J:140085
increased IgG level J:140085
increased inflammatory response J:140085
increased interferon-gamma secretion J:140085
increased interleukin-2 secretion J:140085
increased interleukin-4 secretion J:140085
increased regulatory T cell number J:140085
lung inflammation J:140085
lymph node hyperplasia J:140085
myocarditis J:140085
premature death J:140085
salivary gland inflammation J:140085
spleen hyperplasia J:140085
stomach inflammation J:140085
Ctps1tm1c(KOMP)Wtsi/Ctps1tm1c(KOMP)Wtsi
Tg(Cd4-cre)1Cwi/0
Foxp3sf/Y
Rag1tm1Mom/Rag1+
mixed 		decreased body weight J:348981
decreased inflammatory response J:348981
decreased regulatory T cell number J:348981
decreased T cell proliferation J:348981
enlarged spleen J:348981
thymus hypoplasia J:348981
Dicer1tm1Bdh/Dicer1tm1Bdh
Foxp3tm4(YFP/icre)Ayr/Y
involves: 129S1/Sv * 129X1/SvJ 		blood vessel inflammation J:138683
enlarged lymph nodes J:138683
enlarged spleen J:138683
liver inflammation J:138683
lung inflammation J:138683
premature death J:138683
Dicer1tm1Bdh/Dicer1tm1Bdh
Foxp3tm4(YFP/icre)Ayr/Foxp3tm4(YFP/icre)Ayr
involves: 129S1/Sv * 129X1/SvJ 		blood vessel inflammation J:138683
enlarged lymph nodes J:138683
enlarged spleen J:138683
liver inflammation J:138683
lung inflammation J:138683
premature death J:138683
Droshatm1Litt/Droshatm1.1Litt
Foxp3tm4(YFP/icre)Ayr/Y
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N 		abnormal interferon-gamma secretion J:138683
abnormal interleukin-4 secretion J:138683
abnormal T cell activation J:138683
blood vessel inflammation J:138683
enlarged lymph nodes J:138683
enlarged spleen J:138683
increased CD8-positive, alpha-beta T cell number J:138683
increased leukocyte cell number J:138683
liver inflammation J:138683
lung inflammation J:138683
premature death J:138683
Droshatm1Litt/Droshatm1.1Litt
Foxp3tm4(YFP/icre)Ayr/Foxp3tm4(YFP/icre)Ayr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N 		abnormal interferon-gamma secretion J:138683
abnormal interleukin-4 secretion J:138683
abnormal regulatory T cell morphology J:138683
abnormal T cell activation J:138683
blood vessel inflammation J:138683
enlarged lymph nodes J:138683
enlarged spleen J:138683
increased CD8-positive, alpha-beta T cell number J:138683
increased leukocyte cell number J:138683
liver inflammation J:138683
lung inflammation J:138683
premature death J:138683
Foxo1tm1Flv/Foxo1tm1Flv
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ 		abnormal inflammatory response J:189962
abnormal regulatory T cell physiology J:189962
abnormal skin appearance J:189962
abnormal tail morphology J:189962
enlarged lymph nodes J:189962
enlarged spleen J:189962
hunched posture J:189962
increased CD4-positive, alpha-beta T cell number J:189962
increased CD8-positive, alpha-beta T cell number J:189962
increased interferon-gamma secretion J:189962
increased regulatory T cell number J:189962
increased T cell number J:189962
increased T cell proliferation J:189962
paralysis J:189962
premature death J:189962
Foxo1tm1Flv/Foxo1tm1Flv
Gt(ROSA)26Sortm1(CAG-FOXO1,GFP)Moli/Gt(ROSA)26Sor+
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 		normal immune system phenotype J:189962
normal mortality/aging J:189962
Foxo1tm1Flv/Foxo1tm1Flv
Ifngtm1Ts/Ifngtm1Ts
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129S6/SvEvTac * 129S7/SvEvBrd * 129X1/SvJ 		normal immune system phenotype J:189962
increased CD4-positive, alpha-beta T cell number J:189962
increased CD8-positive, alpha-beta T cell number J:189962
normal mortality/aging J:189962
Foxp3sfOtcspf/Y
involves: 129/Rl 		anemia J:20865
decreased body weight J:20865
decreased hematocrit J:20865
enlarged lymph nodes J:20865
enlarged spleen J:20865
increased CD4-positive, alpha-beta T cell number J:20865
postnatal lethality, incomplete penetrance J:20865
premature death J:20865
skin lesions J:20865
Foxp3tm1.1Ayr/Foxp3tm1.1Ayr
Mir146tm1.1Bal/Mir146tm1.1Bal
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal lymphocyte physiology J:167922
blepharitis J:167922
conjunctivitis J:167922
decreased interferon-gamma secretion J:167922
dermatitis J:167922
increased regulatory T cell number J:167922
premature aging J:167922
Foxp3tm1.1Ayr/Y
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraTcrb)425Cbn/0
Not Specified 		normal immune system phenotype J:97029
no abnormal phenotype detected J:97029
Foxp3tm1.1Mal/Foxp3tm1.1Mal
Lattm1.1Mal/Lattm1.1Mal
involves: 129S2/SvPas * C57BL/6 		abnormal regulatory T cell physiology J:131351
decreased regulatory T cell number J:131351
thymus hypoplasia J:131351
Foxp3tm1Flv/Foxp3+
B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv
Tg(Cd4-cre)1Cwi/?
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 		increased regulatory T cell number J:123547
Foxp3tm1Kuch/?
Il6tm1Kopf/Il6tm1Kopf
involves: 129S2/SvPas * C57BL/6 		abnormal CD4-positive T cell differentiation J:123352
decreased circulating interleukin-6 level J:123352
decreased interleukin-17 secretion J:123352
decreased susceptibility to experimental autoimmune encephalomyelitis J:123352
increased regulatory T cell number J:123352
Foxp3tm1Tch/Y
Stat6tm1Gru/Stat6tm1Gru
C.129-Stat6tm1Gru Foxp3tm1Tch 		abnormal cytokine secretion J:117165
normal immune system phenotype J:117165
increased circulating interferon-gamma level J:117165
increased eosinophil cell number J:117165
lethality at weaning, complete penetrance J:117165
normal respiratory system phenotype J:117165
Foxp3tm2.1(EGFP/cre)Shori/Foxp3tm2.1(EGFP/cre)Shori
Pdcd1tm1Hon/Pdcd1tm1Hon
involves: 129 * 129S2/SvPas * C57BL/6 		premature death J:234397
Foxp3tm2.1(EGFP/cre)Shori/Y
Pdcd1tm1Hon/Pdcd1tm1Hon
involves: 129 * 129S2/SvPas * C57BL/6 		decreased circulating lipase level J:234397
enlarged lymph nodes J:234397
enlarged spleen J:234397
increased effector memory T-helper cell number J:234397
increased susceptibility to autoimmune disorder J:234397
lymph node hyperplasia J:234397
pancreas atrophy J:234397
pancreas inflammation J:234397
premature death J:234397
spleen hyperplasia J:234397
Foxp3tm2Ayr/Foxp3+
Rnf128tm1Cdon/Rnf128tm1Cdon
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal regulatory T cell physiology J:160681
Foxp3tm2Ayr/?
Zap70rps/Zap70rps
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal CD4-positive, alpha beta T cell morphology J:211510
abnormal double-positive T cell morphology J:211510
abnormal regulatory T cell number J:211510
abnormal T cell differentiation J:211510
decreased CD4-positive, alpha-beta T cell number J:211510
decreased CD8-positive, alpha-beta T cell number J:211510
normal immune system phenotype J:211510
Foxp3tm3(HBEGF/GFP)Ayr/Foxp3+
Gpr174tm1Cys/Gpr174+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		decreased susceptibility to experimental autoimmune encephalomyelitis J:222307
Foxp3tm3(HBEGF/GFP)Ayr/Foxp3tm3(HBEGF/GFP)Ayr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal CD4-positive, alpha-beta T cell physiology J:117743
abnormal dendritic cell physiology J:117743
bradykinesia J:117743
cachexia J:117743
conjunctivitis J:117743
decreased T cell number J:117743
dermatitis J:117743
enlarged spleen J:117743
increased dendritic cell number J:117743
increased susceptibility to autoimmune disorder J:117743
increased susceptibility to induced morbidity/mortality J:117743
liver inflammation J:117743
lung inflammation J:117743
lymph node inflammation J:117743
weight loss J:117743
Foxp3tm4(YFP/icre)Ayr/Foxp3+
Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn
involves: 129S1/Sv * 129X1/SvJ 		abnormal regulatory T cell morphology J:205658
abnormal regulatory T cell physiology J:205658
Foxp3tm4(YFP/icre)Ayr/Foxp3tm4(YFP/icre)Ayr
Ikzf4tm1Djr/Ikzf4tm1Djr
involves: 129S1/Sv * 129X1/SvJ 		abnormal small intestine morphology J:294549
chronic inflammation J:294549
decreased regulatory T cell number J:294549
decreased small intestinal microvillus size J:294549
enlarged lymph nodes J:294549
enlarged spleen J:294549
glomerulonephritis J:294549
granulomatous inflammation J:294549
increased germinal center B cell number J:294549
increased immunoglobulin level J:294549
increased spleen B cell follicle number J:294549
increased spleen germinal center number J:294549
increased susceptibility to experimental autoimmune encephalomyelitis J:294549
increased T cell number J:294549
increased T follicular helper cell number J:294549
small intestinal inflammation J:294549
Foxp3tm4(YFP/icre)Ayr/Y
Zfp91tm1Smoc/Zfp91tm1Smoc
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal regulatory T cell physiology J:306129
decreased regulatory T cell number J:306129
increased CD8-positive, alpha-beta T cell number J:306129
increased incidence of tumors by chemical induction J:306129
increased susceptibility to autoimmune disorder J:306129
increased susceptibility to induced colitis J:306129
Foxp3tm9(EGFP/cre/ERT2)Ayr/Foxp3+
Il1r2tm1.1Mchc/Il1r2tm1.1Mchc
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6NTac 		abnormal adaptive immunity J:347877
abnormal alpha-beta T cell number J:347877
increased CD4-positive, alpha-beta T cell number J:347877
increased IgG level J:347877
increased spleen germinal center size J:347877
increased T follicular helper cell number J:347877
Gt(ROSA)26Sortm1(CAG-FOXO1,GFP)Moli/Gt(ROSA)26Sor+
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal immune system phenotype J:189962
Il10tm1Roer/Il10tm1Roer
Foxp3tm4(YFP/icre)Ayr/Y
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal regulatory T cell physiology J:134513
abnormal type IV hypersensitivity reaction J:134513
colitis J:134513
decreased interleukin-10 secretion J:134513
lung inflammation J:134513
Itchtm1.1Alta/Itchtm1.1Alta
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal immunoglobulin level J:204685
abnormal interleukin secretion J:204685
abnormal lymph organ size J:204685
abnormal lymphopoiesis J:204685
abnormal regulatory T cell physiology J:204685
abnormal T-helper 2 cell differentiation J:204685
abnormal T-helper 2 physiology J:204685
decreased CD4-positive, alpha-beta T cell number J:204685
dermatitis J:204685
enlarged lymph nodes J:204685
enlarged spleen J:204685
normal immune system phenotype J:204685
increased CD4-positive, alpha-beta T cell number J:204685
increased CD8-positive, alpha-beta T cell number J:204685
increased eosinophil cell number J:204685
increased IgA level J:204685
increased IgE level J:204685
increased IgG1 level J:204685
increased inflammatory response J:204685
increased interleukin-4 secretion J:204685
increased interleukin-5 secretion J:204685
increased interleukin-10 secretion J:204685
increased interleukin-13 secretion J:204685
increased interleukin-17 secretion J:204685
increased leukocyte cell number J:204685
increased regulatory T cell apoptosis J:204685
increased regulatory T cell number J:204685
lung inflammation J:204685
premature death J:204685
skin lesions J:204685
weight loss J:204685
Itchtm1.1Alta/Itchtm1.1Alta
Gt(ROSA)26Sortm1Hjf/Gt(ROSA)26Sor+
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal immune system phenotype J:204685
increased inflammatory response J:204685
Myd88tm1.1Medz/Myd88tm1.1Medz
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal immune system phenotype J:209373
Nr4a1tm1Pcn/Nr4a1tm1Pcn
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal immune system phenotype J:205658
Nr4a2tm1.1Pcn/Nr4a2+
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129X1/SvJ 		abnormal regulatory T cell morphology J:205658
Pgdtm1.1Pse/Pgdtm1.1Pse
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal CD4-positive helper T cell morphology J:313817
abnormal regulatory T cell physiology J:313817
blepharitis J:313817
decreased body size J:313817
ear inflammation J:313817
enlarged lymph nodes J:313817
enlarged spleen J:313817
increased circulating interferon-gamma level J:313817
increased circulating interleukin-4 level J:313817
increased circulating interleukin-5 level J:313817
increased circulating interleukin-17 level J:313817
increased IgA level J:313817
increased IgD level J:313817
increased IgE level J:313817
increased IgG2a level J:313817
increased IgG3 level J:313817
increased IgM level J:313817
increased interferon-gamma secretion J:313817
increased susceptibility to type I hypersensitivity reaction J:313817
increased T cell number J:313817
premature death J:313817
Pgdtm1.1Pse/Pgdtm1.1Pse
Foxp3tm9(EGFP/cre/ERT2)Ayr/Foxp3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		decreased tumor growth/size J:313817
Socs1tm1Ayos/Socs1tm1Ayos
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ 		blepharitis J:167922
conjunctivitis J:167922
dermatitis J:167922
increased regulatory T cell number J:167922
Tg(Foxp3-HBEGF/EGFP)23.2Spar/0
involves: C57BL/6NCrl 		abnormal pulmonary alveolus morphology J:125295
decreased regulatory T cell number J:125295
enlarged lymph nodes J:125295
enlarged spleen J:125295
epidermal hyperplasia J:125295
normal immune system phenotype J:125295
increased inflammatory response J:125295
increased spleen red pulp amount J:125295
increased spleen white pulp amount J:125295
increased susceptibility to type IV hypersensitivity reaction J:125295
insulitis J:125295
lung inflammation J:125295
lymph node hyperplasia J:125295
skin inflammation J:125295
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11/12/2024
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