Ripk2 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ripk2
receptor (TNFRSF)-interacting serine-threonine kinase 2
MGI:1891456

11 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ripk2^tm1Cfl/Ripk2^tm1Cfl involves: 129S5/SvEvBrd	abnormal macrophage physiology	J:107130
Ripk2^tm1Flv/Ripk2^tm1Flv C.129S1(B6)-Ripk2^tm1Flv/Tvg	decreased tumor incidence following infection	J:329456
Ripk2^tm1Flv/Ripk2^tm1Flv involves: 129S1/Sv	abnormal cytokine secretion	J:75400
	abnormal T-helper 1 physiology	J:75400
	decreased interleukin-6 secretion	J:75400
	decreased T cell proliferation	J:75400
	decreased tumor necrosis factor secretion	J:75400
Ripk2^tm1Flv/Ripk2^tm1Flv involves: 129S1/Sv * C57BL/6	abnormal macrophage physiology	J:132126
	decreased interleukin-6 secretion	J:132126
	decreased tumor necrosis factor secretion	J:132126
Ripk2^tm1Ghc/Ripk2^tm1Ghc involves: 129S4/SvJae * C57BL/6	decreased IgG2a level	J:75401
	decreased interferon-gamma secretion	J:75401
	decreased T cell proliferation	J:75401
	increased susceptibility to infection	J:75401
Ripk2^tm2Cfl/Ripk2^tm2Cfl involves: 129S5/SvEvBrd	normal immune system phenotype	J:107130

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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