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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ripk2
receptor (TNFRSF)-interacting serine-threonine kinase 2
MGI:1891456
11 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ripk2tm1Cfl/Ripk2tm1Cfl
involves: 129S5/SvEvBrd 		abnormal macrophage physiology J:107130
Ripk2tm1Flv/Ripk2tm1Flv
C.129S1(B6)-Ripk2tm1Flv/Tvg 		decreased tumor incidence following infection J:329456
Ripk2tm1Flv/Ripk2tm1Flv
involves: 129S1/Sv 		abnormal cytokine secretion J:75400
abnormal T-helper 1 physiology J:75400
decreased interleukin-6 secretion J:75400
decreased T cell proliferation J:75400
decreased tumor necrosis factor secretion J:75400
Ripk2tm1Flv/Ripk2tm1Flv
involves: 129S1/Sv * C57BL/6 		abnormal macrophage physiology J:132126
decreased interleukin-6 secretion J:132126
decreased tumor necrosis factor secretion J:132126
Ripk2tm1Ghc/Ripk2tm1Ghc
involves: 129S4/SvJae * C57BL/6 		decreased IgG2a level J:75401
decreased interferon-gamma secretion J:75401
decreased T cell proliferation J:75401
increased susceptibility to infection J:75401
Ripk2tm2Cfl/Ripk2tm2Cfl
involves: 129S5/SvEvBrd 		normal immune system phenotype J:107130
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory