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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lgr4
leucine-rich repeat-containing G protein-coupled receptor 4
MGI:1891468
99 phenotypes from 6 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Lgr4Gt(LST020)Byg/Lgr4Gt(LST020)Byg
involves: 129P2/OlaHsd * C57BL/6 		abnormal anterior eye segment morphology J:134299
abnormal canal of Schlemm morphology J:134299
abnormal cornea epithelium morphology J:134299
abnormal cornea morphology J:134299
abnormal cornea stroma morphology J:134299
abnormal iridocorneal angle J:134299
abnormal lens morphology J:134299
abnormal retina morphology J:134299
anterior iris synechia J:134299
cataract J:134299
ciliary body hypoplasia J:134299
cornea deposits J:134299
cornea epithelium hypoplasia J:134299
cornea opacity J:134299
cornea vascularization J:134299
decreased body weight J:134299
decreased cornea epithelium thickness J:134299
decreased cornea stroma thickness J:134299
decreased cornea thickness J:134299
decreased survivor rate J:134299
disorganized retina inner nuclear layer J:134299
disorganized retina outer nuclear layer J:134299
disorganized secondary lens fibers J:134299
embryonic growth retardation J:134299
hypoplastic trabecular meshwork J:134299
increased incidence of corneal inflammation J:134299
iris hypoplasia J:134299
iris stroma hypoplasia J:134299
microphthalmia J:134299
mydriasis J:134299
retina ganglion cell degeneration J:134299
small lens J:134299
thin retina inner nuclear layer J:134299
thin retina outer nuclear layer J:134299
Lgr4Gt(pGT0TMpfs)1Wcs/Lgr4+
involves: 129P2/Ola * C57BL/6 		perinatal lethality, incomplete penetrance J:92077
Lgr4Gt(pGT0TMpfs)1Wcs/Lgr4Gt(pGT0TMpfs)1Wcs
involves: 129P2/Ola * C57BL/6 		abnormal kidney morphology J:92077
decreased body weight J:92077
decreased kidney weight J:92077
decreased liver weight J:92077
enlarged testis J:92077
enlarged uterus J:92077
infertility J:92077
perinatal lethality, incomplete penetrance J:92077
Lgr4Gt(pGT0TMpfs)1Wcs/Lgr4Gt(pGT0TMpfs)1Wcs
involves: 129P2/OlaHsd * C57BL/6 * CD-1 		abnormal efferent ductules of testis morphology J:105945
abnormal epididymal fat pad morphology J:105945
abnormal epididymis epithelium morphology J:105945
abnormal epididymis morphology J:105945
abnormal rete testis morphology J:105945
abnormal seminiferous tubule epithelium morphology J:105945
abnormal testis morphology J:105945
abnormal testis physiology J:105945
decreased body size J:105945
decreased body weight J:105945
decreased epididymal cell proliferation J:105945
epididymal cyst J:105945
epididymis hypoplasia J:105945
male infertility J:105945
postnatal lethality, incomplete penetrance J:105945
rete testis obstruction J:105945
small caput epididymis J:105945
Lgr4Gt(pU-21)1Kymm/Lgr4Gt(pU-21)1Kymm
B6.Cg-Lgr4Gt(pU-21)1Kymm 		postnatal lethality, incomplete penetrance J:121125
Lgr4Gt(pU-21)1Kymm/Lgr4Gt(pU-21)1Kymm
CBA.Cg-Lgr4Gt(pU-21)1Kymm 		abnormal caput epididymis morphology J:121125
abnormal epididymis morphology J:121125
abnormal reproductive system morphology J:121125
abnormal reproductive system physiology J:121125
abnormal seminiferous tubule epithelium morphology J:121125
abnormal sperm number J:121125
abnormal testis morphology J:121125
asthenozoospermia J:121125
decreased epididymis weight J:121125
dilated rete testis J:121125
increased testis weight J:121125
male infertility J:121125
postnatal growth retardation J:121125
postnatal lethality, incomplete penetrance J:121125
reduced female fertility J:121125
Lgr4tm1.1(cre/ERT2)Npa/Lgr4tm1.1(cre/ERT2)Npa
involves: C57BL/6 		abnormal epidermal stem cell proliferation J:212415
abnormal glomerular capsule space morphology J:212415
abnormal intestine development J:212415
abnormal intestine physiology J:212415
abnormal skin development J:212415
decreased hair follicle number J:212415
dilated renal tubule J:212415
kidney cyst J:212415
perinatal lethality, complete penetrance J:212415
prenatal lethality, incomplete penetrance J:212415
normal renal/urinary system phenotype J:212415
thin epidermis J:212415
Lgr4tm1.1Knis/Lgr4tm1.1Knis
Tg(Cyp1a1-cre)1Dwi/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal small intestinal crypt cell proliferation J:174842
decreased small intestinal villus size J:174842
premature death J:174842
Lgr4tm1.1Knis/Lgr4tm1.1Knis
Tg(KRT5-cre)1Tak/0
involves: 129P2/OlaHsd * C3H * C57BL/6 * SJL 		eyelids open at birth J:126813
normal growth/size/body region phenotype J:126813
normal mortality/aging J:126813
Lgr4tm1.2Knis/Lgr4+
involves: 129P2/OlaHsd * C57BL/6 		perinatal lethality, incomplete penetrance J:127019
Lgr4tm1.2Knis/Lgr4tm1.2Knis
B6.129P2-Lgr4tm1.2Knis 		abnormal metanephric mesenchyme morphology J:186318
abnormal metanephric ureteric bud development J:172277
impaired branching involved in ureteric bud morphogenesis J:172277
increased kidney apoptosis J:186318
kidney cyst J:172277
lethality throughout fetal growth and development, incomplete penetrance J:172277
perinatal lethality, complete penetrance J:172277
renal hypoplasia J:172277
small metanephros J:172277
Lgr4tm1.2Knis/Lgr4tm1.2Knis
involves: 129P2/OlaHsd * C57BL/6 		abnormal keratinocyte physiology J:126813
abnormal kidney morphology J:127019
abnormal nephron morphology J:127019
decreased fetal weight J:127019
decreased kidney weight J:127019
decreased renal glomerulus number J:127019
eyelids open at birth J:126813
increased circulating creatinine level J:127019
lethality throughout fetal growth and development, incomplete penetrance J:127019
neonatal lethality, incomplete penetrance J:127019
perinatal lethality, incomplete penetrance J:127019
polycystic kidney J:127019
postnatal growth retardation J:127019
premature death J:127019
renal hypoplasia J:127019
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory