Pnkp Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pnkp
polynucleotide kinase 3'- phosphatase
MGI:1891698

25 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pnkp^em1(IMPC)Mbp/Pnkp⁺ C57BL/6NCrl-Pnkp^em1(IMPC)Mbp/MbpMmucd	abnormal eye morphology	J:211773
	abnormal kidney morphology	J:211773
	abnormal skin morphology	J:211773
	enlarged kidney	J:211773
	microphthalmia	J:211773
	single kidney	J:211773
Pnkp^em1(IMPC)Mbp/Pnkp^em1(IMPC)Mbp C57BL/6NCrl-Pnkp^em1(IMPC)Mbp/MbpMmucd	embryonic lethality prior to organogenesis	J:211773
	preweaning lethality, complete penetrance	J:211773
Pnkp^tm1.1Pmc/Pnkp^tm1.1Pmc Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ involves: 129S1/Sv * C57BL/6 * CBA	embryonic lethality, complete penetrance	J:226703
Pnkp^tm1.1Pmc/Pnkp^tm1.1Pmc Emx1^tm1(cre)Krj/Emx1⁺ involves: 129S1/Sv * 129S2/SvPas * C57BL/6	abnormal cerebellar cortex morphology	J:226703
	decreased body size	J:226703
	decreased brain size	J:226703
	decreased cell proliferation	J:226703
	increased brain apoptosis	J:226703
Pnkp^tm1.1Pmc/Pnkp^tm1.1Pmc Tg(CAG-cre/Esr1)5Amc/0 involves: 129S1/Sv C57BL/6 * CBA	abnormal cerebellar cortex morphology	J:226703
	abnormal myelination	J:226703
	decreased body size	J:226703
	decreased brain size	J:226703
	decreased neuron number	J:226703
	decreased oligodendrocyte number	J:226703
	increased brain apoptosis	J:226703
Pnkp^tm1.1Pmc/Pnkp^tm1.1Pmc Tg(Nes-cre)1Kln/0 involves: 129S1/Sv * C57BL/6 * SJL	abnormal brain interneuron morphology	J:226703
	abnormal cerebellar cortex morphology	J:226703
	abnormal DNA repair	J:226703
	abnormal double-strand DNA break repair	J:226703
	abnormal single-strand DNA break repair	J:226703
	decreased cell proliferation	J:226703
	decreased neuron number	J:226703
	increased brain apoptosis	J:226703
	intracranial hemorrhage	J:226703
	postnatal lethality, complete penetrance	J:226703
Pnkp^tm1Pmc/Pnkp^tm1Pmc involves: 129S1/Sv * C57BL/6	abnormal cerebellar cortex morphology	J:226703
	abnormal DNA repair	J:226703
	abnormal double-strand DNA break repair	J:226703
	abnormal single-strand DNA break repair	J:226703
	decreased brain size	J:226703
	decreased cell proliferation	J:226703
	increased brain apoptosis	J:226703
	microcephaly	J:226703
	small cerebellum	J:226703
Pnkp^tm2.1Pmc/Pnkp^tm2.1Pmc involves: C57BL/6	embryonic lethality, complete penetrance	J:226703

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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