Ncstn Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ncstn
nicastrin
MGI:1891700

57 phenotypes from 7 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ncstn^tm1.1Akli/Ncstn^tm1.1Akli Tg(Mx1-cre)1Cgn/0 involves: 129 * C57BL/6 * CBA * SJL	abnormal definitive hematopoiesis	J:172442
	abnormal hematopoietic stem cell morphology	J:172442
	abnormal spleen morphology	J:172442
	enlarged spleen	J:172442
	increased hematopoietic stem cell number	J:172442
	increased leukemia incidence	J:172442
	increased leukocyte cell number	J:172442
	increased monocyte cell number	J:172442
	increased spleen red pulp amount	J:172442
	premature death	J:172442
Ncstn^tm1.1Akli/Ncstn^tm1.1Akli Tg(Upk2-cre,-EGFP)#Akli/0 involves: 129	hydronephrosis	J:227748
	increased urinary bladder carcinoma incidence	J:227748
	ureter obstruction	J:227748
Ncstn^tm1.1Akli/Ncstn^tm1.1Akli Tg(VAV1-cre)1Graf/0 involves: 129	abnormal splenocyte physiology	J:196407
	enlarged spleen	J:196407
	premature death	J:196407
Ncstn^tm1.1Akli/Ncstn^tm1.1Akli Tg(VAV1-cre)1Graf/0 involves: 129 * C57BL/6 * SJL	abnormal definitive hematopoiesis	J:172442
	abnormal hematopoietic stem cell morphology	J:172442
	abnormal spleen morphology	J:172442
	enlarged spleen	J:172442
	increased hematopoietic stem cell number	J:172442
	increased leukemia incidence	J:172442
	increased leukocyte cell number	J:172442
	increased monocyte cell number	J:172442
	increased spleen red pulp amount	J:172442
	premature death	J:172442
Ncstn^tm1.1Sud/Ncstn^tm1.1Sud Olig1^tm1(cre)Rth/Olig1⁺ involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	abnormal coat appearance	J:234705
	decreased myelin sheath thickness	J:234705
	decreased prepulse inhibition	J:234705
	dysmyelination	J:234705
	hyperactivity	J:234705
	increased exploration in new environment	J:234705
	increased grooming behavior	J:234705
	increased stereotypic behavior	J:234705
	skin lesions	J:234705
Ncstn^tm1.1Sud/Ncstn^tm1.1Sud Tg(Camk2a-cre)1Shn/0 B6.Cg-Ncstn^tm1.1Sud Tg(Camk2a-cre)1Shn	abnormal dendrite morphology	J:149506
	abnormal spatial learning	J:149506
	astrocytosis	J:149506
	normal behavior/neurological phenotype	J:149506
	decreased CNS synapse formation	J:149506
	gliosis	J:149506
	impaired contextual conditioning behavior	J:149506
	impaired spatial working memory	J:149506
	increased neuron apoptosis	J:149506
	loss of cortex neurons	J:149506
	normal nervous system phenotype	J:149506
	thin cerebral cortex	J:149506
Ncstn^tm1.2Sud/Ncstn^tm1.2Sud involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	embryonic lethality, complete penetrance	J:149506
Ncstn^tm1Jli/Ncstn^tm1Jli involves: 129S5/SvEvBrd * C57BL/6	abnormal somite development	J:85205
Ncstn^tm1Jli/Ncstn^tm1Jli involves: 129S5/SvEvBrd * C57BL/6	embryonic lethality, complete penetrance	J:85205
Ncstn^tm1Pcw/Ncstn^tm1Pcw involves: 129X1/SvJ * C57BL/6	abnormal cell physiology	J:83376
	abnormal heart development	J:83376
	abnormal neural tube morphology	J:83376
	abnormal vitelline vasculature morphology	J:83376
	caudal body truncation	J:83376
	distended pericardium	J:83376
	embryonic growth retardation	J:83376
	embryonic lethality during organogenesis, complete penetrance	J:83376
	failure of heart looping	J:83376
	failure of somite differentiation	J:83376
	kinked neural tube	J:83376
	small heart	J:83376
Ncstn^tm1Rroz/Ncstn^tm1Rroz involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal first pharyngeal arch morphology	J:108976
	abnormal neural crest morphology	J:108976
	abnormal optic vesicle formation	J:108976
	abnormal rostral-caudal body axis extension	J:108976
	abnormal somite development	J:108976
	abnormal vitelline vasculature morphology	J:108976
	decreased embryo size	J:108976
	embryonic lethality during organogenesis, complete penetrance	J:108976
	increased apoptosis	J:108976
	increased embryonic neuroepithelium apoptosis	J:108976
	kinked neural tube	J:108976
Ncstn^tm1Sud/Ncstn^tm1Sud involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	no abnormal phenotype detected	J:149506

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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