Spen Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Spen
spen family transcription repressor
MGI:1891706

21 phenotypes from 4 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cd19^tm1(cre)Cgn/Cd19⁺ Spen^tm2.1Hon/Spen^tm2.1Hon involves: 129P2/OlaHsd * C57BL/6 * CBA	decreased follicular B cell number	J:121523
	increased marginal zone B cell number	J:121523
Spen^tm1Hon/Spen^tm1Hon involves: 129P2/OlaHsd * C57BL/6J	abnormal B cell differentiation	J:82332
	abnormal heart development	J:82332
	abnormal pancreas development	J:82332
	lethality throughout fetal growth and development, complete penetrance	J:82332
	liver hypoplasia	J:82332
	small liver	J:82332
	translucent skin	J:82332
Spen^tm2.1Hon/Spen^tm2.1Hon Tg(Camk2a-cre)10Kmik/? involves: C57BL/6 * CBA	abnormal brain size	J:121523
	abnormal contextual conditioning behavior	J:121523
	abnormal cued conditioning behavior	J:121523
	abnormal learning/memory/conditioning	J:121523
Spen^tm2.1Hon/Spen^tm2.1Hon Tg(Nes-cre)1Kag/? involves: C57BL/6 * CBA	abnormal telencephalon morphology	J:121523
	decreased brain weight	J:121523
	enlarged lateral ventricles	J:121523
	postnatal growth retardation	J:121523
	premature death	J:121523
	small hippocampus	J:121523
	thin cerebral cortex	J:121523
Spen^tm2.2Hon/Spen^tm2.2Hon involves: C57BL/6 * CBA	prenatal lethality, complete penetrance	J:121523
Spen^tm2Hon/Spen^tm2Hon involves: C57BL/6 * CBA	prenatal lethality, complete penetrance	J:121523

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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