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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Becn1
beclin 1, autophagy related
MGI:1891828
72 phenotypes from 8 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Becn1tm1.1Bflu/Becn1tm1.1Bflu
Tg(Cd4-cre)1Cwi/0
involves: 129S1/Sv * C57BL/6 * DBA/2 		abnormal CD4-positive, alpha-beta T cell physiology J:203090
decreased CD4-positive, alpha-beta T cell number J:203090
decreased CD8-positive, alpha-beta T cell number J:203090
decreased susceptibility to experimental autoimmune encephalomyelitis J:203090
decreased T cell proliferation J:203090
increased T cell apoptosis J:203090
Becn1tm1.1Ebr/Becn1+
Not Specified 		abnormal ovary morphology J:180916
Becn1tm1b(KOMP)Wtsi/Becn1+
C57BL/6N-Becn1tm1b(KOMP)Wtsi/Ieg 		decreased circulating HDL cholesterol level J:211773
decreased lean body mass J:211773
increased circulating bilirubin level J:211773
increased leukocyte cell number J:211773
increased startle reflex J:211773
increased total body fat amount J:211773
Becn1tm1b(KOMP)Wtsi/Becn1tm1b(KOMP)Wtsi
C57BL/6N-Becn1tm1b(KOMP)Wtsi/Ieg 		preweaning lethality, complete penetrance J:211773
Becn1tm1Blev/Becn1+
involves: 129X1/SvJ * C57BL/6J 		abnormal immune system morphology J:86953
abnormal mammary gland duct morphology J:86953
decreased tumor-free survival time J:86953
impaired autophagy J:86953
increased follicular lymphoma incidence J:86953
increased hepatocellular carcinoma incidence J:86953
increased histiocytic sarcoma incidence J:86953
increased lung adenocarcinoma incidence J:86953
increased lung adenoma incidence J:86953
increased lung carcinoma incidence J:86953
increased lymphoma incidence J:86953
increased malignant tumor incidence J:86953
increased mammary gland tumor incidence J:86953
increased plasmacytoma incidence J:86953
increased spleen germinal center number J:86953
increased spleen germinal center size J:86953
increased tumor incidence J:86953
Becn1tm1Blev/Becn1tm1Blev
involves: 129X1/SvJ 		decreased myocardial infarct size J:186597
increased myocardial infarct size J:186597
Becn1tm1Blev/Becn1tm1Blev
involves: 129X1/SvJ * C57BL/6J 		prenatal lethality, complete penetrance J:86953
Becn1tm1Ebr/Becn1+
Tg(EIIa-cre)C5379Lmgd/?
involves: FVB/N 		abnormal brain development J:180916
abnormal heart development J:180916
embryonic lethality during organogenesis, incomplete penetrance J:180916
Becn1tm1Ebr/Becn1+
Tg(MMTV-cre)1Mam/?
involves: FVB 		abnormal brain development J:180916
abnormal heart development J:180916
abnormal primordial ovarian follicle morphology J:180916
decreased primordial ovarian follicle number J:180916
embryonic lethality during organogenesis, incomplete penetrance J:180916
perinatal lethality J:180916
small ovary J:180916
Becn1tm1Ebr/Becn1tm1Ebr
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd 		abnormal circulating chemokine level J:235399
abnormal kidney morphology J:235399
abnormal macrophage physiology J:235399
abnormal renal glomerulus morphology J:235399
abnormal spleen morphology J:235399
decreased body weight J:235399
decreased circulating interleukin-10 level J:235399
glomerulonephritis J:235399
increased anti-double stranded DNA antibody level J:235399
increased anti-nuclear antigen antibody level J:235399
increased autoantibody level J:235399
increased blood urea nitrogen level J:235399
increased circulating creatinine level J:235399
increased circulating interleukin-1 beta level J:235399
increased circulating interleukin-6 level J:235399
increased circulating interleukin-12b level J:235399
increased IgG level J:235399
increased lymphocyte cell number J:235399
increased monocyte cell number J:235399
increased neutrophil cell number J:235399
increased susceptibility to systemic lupus erythematosus J:235399
increased urine protein level J:235399
Becn1tm1Htz/Becn1+
involves: 129P2/OlaHsd * C57BL/6 		increased B cell derived lymphoma incidence J:86982
increased hepatocellular carcinoma incidence J:86982
increased lung adenocarcinoma incidence J:86982
increased tumor incidence J:86982
Becn1tm1Htz/Becn1tm1Htz
involves: 129P2/OlaHsd 		abnormal amnion morphology J:86982
absent amniotic folds J:86982
decreased embryo size J:86982
embryonic growth arrest J:86982
embryonic lethality between implantation and somite formation, complete penetrance J:86982
impaired autophagy J:86982
increased embryonic tissue cell apoptosis J:86982
Becn1tm1Smoc/Becn1tm1Smoc
Foxp3tm4(YFP/icre)Ayr/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal regulatory T cell physiology J:306129
Becn1tm2.1Blev/Becn1tm2.1Blev
B6.129-Becn1tm2.1Blev 		no abnormal phenotype detected J:244104
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory