Mkks Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mkks
McKusick-Kaufman syndrome
MGI:1891836

26 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Mkks^{Gt(OST367255)Lex}/Mkks^{Gt(OST367255)Lex} involves: 129S5/SvEvBrd * C57BL/6J	abnormal inner hair cell kinocilium location or orientation	J:102697
	abnormal olfactory epithelium morphology	J:102697
	abnormal orientation of outer hair cell stereociliary bundles	J:102697
	absent distortion product otoacoustic emissions	J:102697
	absent pinna reflex	J:102697
	anosmia	J:102697
	exencephaly	J:102697
	eyelids open at birth	J:102697
	increased susceptibility to age-related retinal degeneration	J:102697
Mkks^tm1Vcs/Mkks^tm1Vcs either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)	abnormal olfaction	J:99276
	absent sperm flagellum	J:99276
	decreased aggression	J:99276
	decreased body weight	J:99276
	decreased locomotor activity	J:99276
	decreased vocalization	J:99276
	increased circulating leptin level	J:99276
	increased susceptibility to age-related retinal degeneration	J:99276
	increased systemic arterial blood pressure	J:99276
	normal limbs/digits/tail phenotype	J:99276
	male infertility	J:99276
	obese	J:99276
	prenatal lethality, incomplete penetrance	J:99276
Mkks^tm1Vcs/Mkks^tm1Vcs involves: 129S1/Sv * 129X1/SvJ	decreased striatum size	J:128532
	enlarged lateral ventricles	J:128532
	enlarged third ventricle	J:128532
	small hippocampus	J:128532
	thin cerebral cortex	J:128532

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24