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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Trem2
triggering receptor expressed on myeloid cells 2
MGI:1913150
16 phenotypes from 3 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Trem2em2Bwef/Trem2+
involves: C57BL/6J * DBA/2J * FVB/N 		decreased macrophage cell number J:242126
Trem2em2Bwef/Trem2em2Bwef
involves: C57BL/6J * DBA/2J * FVB/N 		abnormal blood volume J:242126
abnormal glucose homeostasis J:242126
decreased macrophage cell number J:242126
decreased macrophage proliferation J:242126
decreased microglial cell activation J:242126
impaired macrophage phagocytosis J:242126
increased circulating interleukin-6 level J:242126
increased circulating tumor necrosis factor level J:242126
increased macrophage apoptosis J:242126
increased susceptibility to endotoxin shock J:242126
Trem2tm1(KOMP)Vlcg/Trem2tm1(KOMP)Vlcg
C57BL/6N-Trem2tm1(KOMP)Vlcg 		abnormal cell cycle checkpoint function J:239381
abnormal glial cell apoptosis J:239381
abnormal microglial cell physiology J:239381
decreased microglial cell activation J:239381
Trem2tm1Cln/Trem2tm1Cln
B6.129P2-Trem2tm1Cln 		abnormal interferon level J:138057
abnormal interleukin level J:138057
abnormal tumor necrosis factor level J:138057
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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10/29/2024
MGI 6.24 		The Jackson Laboratory