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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Sharpin
SHANK-associated RH domain interacting protein
MGI:1913331
69 phenotypes from 2 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Sharpincpdm-Dem/Sharpincpdm-Dem
CBy.OcB3-Sharpincpdm-Dem 		abnormal immune system organ morphology J:121810
dermatitis J:121810
skin inflammation J:121810
Sharpincpdm/Sharpincpdm
C57BL/KaLawRij-Sharpincpdm 		abnormal angiogenesis J:14539
abnormal coat appearance J:31745
abnormal dermal layer morphology J:14539
abnormal epidermal layer morphology J:14539
abnormal epidermis stratum basale morphology J:14539
abnormal epidermis stratum corneum morphology J:31745
abnormal epidermis stratum granulosum morphology J:14539
abnormal esophageal epithelium morphology J:14539, J:31745
abnormal hair follicle morphology J:14539
abnormal hair shaft morphology J:14539
abnormal humoral immune response J:53575
abnormal immune system organ morphology J:14539
abnormal liver morphology J:14539, J:31745
abnormal lung interstitium morphology J:14539
abnormal lymph node morphology J:14539
abnormal mesenteric lymph node morphology J:53575
abnormal peripheral lymph node morphology J:53575
abnormal spleen morphology J:53575
abnormal spleen white pulp morphology J:31745, J:53575
abnormal stomach epithelium morphology J:14539
abnormal synovial joint capsule morphology J:14539
abnormal tongue squamous epithelium morphology J:31745
absent Peyer's patches J:53575
absent spleen B cell follicles J:53575
absent spleen germinal center J:53575
absent spleen marginal zone J:53575
acanthosis J:31745
alopecia J:68129
cutaneous mastocytosis J:14539, J:31745
decreased B cell number J:53575
decreased CD4-positive, alpha-beta T cell number J:53575
decreased IgA level J:53575
decreased IgE level J:31745, J:53575
decreased IgG level J:53575
decreased immunoglobulin level J:53575
decreased T cell number J:53575
dermatitis J:14539
enlarged spleen J:14539, J:53575
epidermal hyperplasia J:14539
esophageal inflammation J:31745
extramedullary hematopoiesis J:14539, J:31745, J:53575
female infertility J:14539
folliculitis J:31745
hyperkeratosis J:14539, J:31745
increased bone marrow cell number J:14539
increased eosinophil cell number J:14539, J:31745
increased IgM level J:53575
increased keratinocyte apoptosis J:14539, J:31745, J:53575
increased keratinocyte proliferation J:31745
increased pruritus J:31745
joint inflammation J:14539
large lymphoid organs J:31745
lung inflammation J:31745
lymph node inflammation J:31745
mixed cellular infiltration to dermis J:14539, J:31745, J:53575
parakeratosis J:14539, J:31745
postnatal growth retardation J:14539
premature hair loss J:14539, J:31745
reddish skin J:14539, J:31745
reduced male fertility J:31745
scaly skin J:14539, J:31745, J:68129
skin edema J:14539
skin lesions J:14539, J:31745
stomach inflammation J:31745
thick epidermis J:14539, J:31745
thick epidermis stratum basale J:31745
thick eyelids J:31745
weight loss J:31745
Sharpincpdm/Sharpincpdm
involves: C57BL/KaLawRij * CAST/EiJ 		alopecia J:68129
scaly skin J:68129
Sharpincpdm/Sharpincpdm
involves: C57BL/KaLawRij * FVB/NJ 		absent Peyer's patches J:121810
absent spleen B cell follicles J:121810
absent spleen germinal center J:121810
skin inflammation J:121810
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory