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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ier3ip1
immediate early response 3 interacting protein 1
MGI:1913441
23 phenotypes from 2 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ier3ip1em1(IMPC)J/Ier3ip1+
C57BL/6NJ-Ier3ip1em1(IMPC)J/Mmjax 		abnormal vocalization J:211773
decreased locomotor activity J:211773
increased circulating alanine transaminase level J:211773
Ier3ip1em1(IMPC)J/Ier3ip1em1(IMPC)J
C57BL/6NJ-Ier3ip1em1(IMPC)J/Mmjax 		embryonic lethality prior to organogenesis J:211773
preweaning lethality, complete penetrance J:211773
Ier3ip1tm1Arvn/Ier3ip1tm1Arvn
Tg(Ins1-cre/ERT)1Lphi/0
involves: 129S4/SvJaeSor * C57BL/6J * CD-1 		abnormal glucose homeostasis J:336782
abnormal pancreatic beta cell differentiation J:336782
abnormal pancreatic beta cell morphology J:336782
decreased circulating insulin level J:336782
decreased insulin secretion J:336782
decreased pancreatic beta cell proliferation J:336782
hyperglycemia J:336782
impaired glucose tolerance J:336782
increased pancreatic beta cell apoptosis J:336782
Ier3ip1tm1Arvn/Ier3ip1tm1Arvn
Tg(Ins2-cre)25Mgn/0
involves: C57BL/6 * C57BL/6J * DBA 		abnormal endoplasmic reticulum morphology J:336782
abnormal endoplasmic reticulum physiology J:336782
abnormal glucose homeostasis J:336782
abnormal pancreatic beta cell differentiation J:336782
abnormal pancreatic beta cell morphology J:336782
decreased body weight J:336782
decreased circulating insulin level J:336782
decreased insulin secretion J:336782
decreased pancreatic beta cell mass J:336782
decreased pancreatic beta cell proliferation J:336782
hyperglycemia J:336782
impaired glucose tolerance J:336782
increased circulating glucose level J:336782
increased endoplasmic reticulum stress J:336782
increased fasting circulating glucose level J:336782
increased pancreatic beta cell apoptosis J:336782
slow postnatal weight gain J:336782
small pancreatic islets J:336782
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory