About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Smurf2
SMAD specific E3 ubiquitin protein ligase 2
MGI:1913563
15 phenotypes from 4 alleles in 4 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Smurf2Gt(RRA098)Byg/Smurf2+
involves: 129P2/OlaHsd * C57BL/6 		delayed cellular replicative senescence J:189320
increased lymphoma incidence J:189320
increased tumor incidence J:189320
Smurf2Gt(RRA098)Byg/Smurf2Gt(RRA098)Byg
involves: 129P2/OlaHsd * C57BL/6 		delayed cellular replicative senescence J:189320
enlarged spleen J:189320
increased B cell derived lymphoma incidence J:189320, J:245679
increased hepatocellular carcinoma incidence J:189320
increased lymphoma incidence J:189320
increased sarcoma incidence J:189320
increased small intestine adenocarcinoma incidence J:189320
increased tumor incidence J:189320
Smurf2tm1b(EUCOMM)Wtsi/Smurf2tm1b(EUCOMM)Wtsi
C57BL/6N-Smurf2tm1b(EUCOMM)Wtsi/H 		preweaning lethality, incomplete penetrance J:211773
Smurf2tm1Wran/Smurf2tm1Wran
involves: 129S1/Sv * 129X1/SvJ * ICR 		no abnormal phenotype detected J:148693
Smurf2tm1Yez/Smurf2tm1Yez
either: B6.129S6-Smurf2tm1Yez or (involves: 129S6/SvEvTac * NIH Black Swiss) 		abnormal cell physiology J:180221
abnormal tail morphology J:180221
abnormal vertebrae morphology J:180221
hydrocephaly J:180221
kinked tail J:180221
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory