Sar1b Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sar1b
secretion associated Ras related GTPase 1B
MGI:1913647

18 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sar1b^em1Emle/Sar1b⁺ C57BL/6N-Sar1b^em1Emle	abnormal circulating non-HDL cholesterol level	J:319817
	abnormal intestinal lipid absorption	J:319817
	abnormal lipid metabolism	J:319817
	decreased circulating cholesterol level	J:319817
	decreased circulating HDL cholesterol level	J:319817
	decreased circulating triglyceride level	J:319817
	decreased lipogenesis	J:319817
Sar1b^em1Emle/Sar1b^em1Emle C57BL/6N-Sar1b^em1Emle	lethality throughout fetal growth and development, incomplete penetrance	J:319817
Sar1b^em1Emle/Sar1b^em1Emle involves: 129 * C57BL/6N	lethality throughout fetal growth and development, complete penetrance	J:319817
Sar1b^em2Emle/Sar1b⁺ C57BL/6N-Sar1b^em2Emle	abnormal circulating non-HDL cholesterol level	J:319817
	abnormal intestinal lipid absorption	J:319817
	abnormal lipid metabolism	J:319817
	decreased circulating cholesterol level	J:319817
	decreased circulating HDL cholesterol level	J:319817
	decreased circulating triglyceride level	J:319817
	decreased lipogenesis	J:319817
	increased liver cholesterol level	J:319817
	steatorrhea	J:319817
Sar1b^em2Emle/Sar1b^em2Emle C57BL/6N-Sar1b^em2Emle	lethality throughout fetal growth and development, complete penetrance	J:319817
Sar1b^em2Emle/Sar1b^em2Emle involves: 129 * C57BL/6N	lethality throughout fetal growth and development, complete penetrance	J:319817
Sar1b^{tm1a(EUCOMM)Wtsi}/Sar1b⁺ C57BL/6N-Sar1b^{tm1a(EUCOMM)Wtsi}/Wtsi	abnormal skin condition	J:175295
	decreased circulating alanine transaminase level	J:175295
	decreased circulating cholesterol level	J:175295
	decreased circulating free fatty acids level	J:175295
	decreased circulating HDL cholesterol level	J:175295
	decreased circulating LDL cholesterol level	J:175295
	increased circulating free fatty acids level	J:175295
	increased mean corpuscular hemoglobin	J:175295
Sar1b^{tm1a(EUCOMM)Wtsi}/Sar1b^{tm1a(EUCOMM)Wtsi} C57BL/6N-Sar1b^{tm1a(EUCOMM)Wtsi}/Wtsi	preweaning lethality, complete penetrance	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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