Nmnat1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nmnat1
nicotinamide nucleotide adenylyltransferase 1
MGI:1913704

34 phenotypes from 7 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nmnat1^imh/Nmnat1^imh B6J.C(C3H)-Nmnat1^imh	abnormal retina inner nuclear layer morphology	J:234111
	abnormal retina vasculature morphology	J:234111
	normal behavior/neurological phenotype	J:234111
	decreased a-wave amplitude	J:234111
	decreased b-wave amplitude	J:234111
	decreased total retina thickness	J:234111
	disorganized retina inner nuclear layer	J:234111
	normal growth/size/body region phenotype	J:234111
	impaired pupillary reflex	J:234111
	increased susceptibility to age-related retinal degeneration	J:234111
	normal mortality/aging	J:234111
	photoreceptor inner segment degeneration	J:234111
	photoreceptor outer segment degeneration	J:234111
	normal reproductive system phenotype	J:234111
	retina outer nuclear layer degeneration	J:234111
	retina photoreceptor degeneration	J:234111
	retina pigment epithelium atrophy	J:234111
	thin retina inner nuclear layer	J:234111
	thin retina outer nuclear layer	J:234111
Nmnat1^tm1.2Lcon/Nmnat1⁺ involves: C57BL/6 * DBA/2	normal nervous system phenotype	J:190793
Nmnat1^tm1.2Lcon/Nmnat1^tm1.2Lcon involves: C57BL/6 * DBA/2	prenatal lethality, complete penetrance	J:190793
Nmnat1^{tm1a(EUCOMM)Wtsi}/Nmnat1⁺ C57BL/6N-Nmnat1^{tm1a(EUCOMM)Wtsi}/Cnrm	abnormal bone mineralization	J:165965
	abnormal bone structure	J:165965
	increased mean corpuscular volume	J:165965
Nmnat1^{tm1c(EUCOMM)Wtsi}/Nmnat1^{tm1c(EUCOMM)Wtsi} Tg(Chx10-EGFP/cre,-ALPP)2Clc/0 involves: C57BL/6J * C57BL/6N * SJL	decreased total retina thickness	J:267630
	retina degeneration	J:267630
	thin retina inner nuclear layer	J:267630
	thin retina outer nuclear layer	J:267630
Nmnat1^{tm1c(EUCOMM)Wtsi}/Nmnat1^{tm1c(EUCOMM)Wtsi} Tg(Crx-cre/ERT2)1Tfur/0 involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N	abnormal retina morphology	J:267630
	decreased total retina thickness	J:267630
	retina outer nuclear layer degeneration	J:267630
	retina photoreceptor degeneration	J:267630
	short photoreceptor outer segment	J:267630
Nmnat1^{tm1c(EUCOMM)Wtsi}/Nmnat1^{tm1c(EUCOMM)Wtsi} Tg(Rho-icre)1Ck/0 involves: C57BL/6J * C57BL/6N * SJL	abnormal retina rod cell outer segment morphology	J:267630
	retina degeneration	J:267630
	retina outer nuclear layer degeneration	J:267630
	retina rod cell degeneration	J:267630
Nmnat1^{tm1d(EUCOMM)Wtsi}/Nmnat1^{tm1d(EUCOMM)Wtsi} involves: 129S1/Sv * C57BL/6J * C57BL/6N	embryonic lethality, complete penetrance	J:267630
Nmnat1^tm1Ruch/Nmnat1^{tm1d(EUCOMM)Wtsi} involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J * C57BL/6N	decreased a-wave amplitude	J:267630
	decreased b-wave amplitude	J:267630
	increased endoplasmic reticulum stress	J:267630
	photoreceptor outer segment degeneration	J:267630
	retina degeneration	J:267630
	retina outer nuclear layer degeneration	J:267630
	retina photoreceptor degeneration	J:267630
Nmnat1^tm1Ruch/Nmnat1^tm1Ruch involves: 129S7/SvEvBrd	no abnormal phenotype detected	J:267630
Nmnat1^tvrm113/Nmnat1^tvrm113 C57BL/6J-Nmnat1^tvrm113/Pjn	abnormal cone electrophysiology	J:234111
	abnormal retina morphology	J:234111
	abnormal retina vasculature morphology	J:234111
	abnormal rod electrophysiology	J:234111
	normal behavior/neurological phenotype	J:234111
	decreased a-wave amplitude	J:234111
	decreased b-wave amplitude	J:234111
	decreased total retina thickness	J:234111
	normal growth/size/body region phenotype	J:234111
	normal mortality/aging	J:234111
	normal reproductive system phenotype	J:234111
	retina degeneration	J:234111
	retina photoreceptor degeneration	J:234111
	retina pigment epithelium atrophy	J:234111

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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