Ptpmt1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ptpmt1
protein tyrosine phosphatase, mitochondrial 1
MGI:1913711

26 phenotypes from 5 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ptpmt1^{tm1.1(KOMP)Vlcg}/Ptpmt1^{tm1.1(KOMP)Vlcg} C57BL/6N-Ptpmt1^{tm1.1(KOMP)Vlcg}/Ucd	embryonic lethality prior to organogenesis	J:211773
	preweaning lethality, complete penetrance	J:211773
Ptpmt1^tm1.1Jedi/Ptpmt1^tm1.1Jedi involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	abnormal aerobic respiration	J:176087
	abnormal cell physiology	J:176087
	abnormal mitochondrial morphology	J:176087
	decreased cell proliferation	J:176087
Ptpmt1^tm1.2Jedi/Ptpmt1^tm1.2Jedi involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * SJL	embryonic lethality between implantation and placentation, complete penetrance	J:176087
Ptpmt1^tm1Ckq/Ptpmt1^tm1Ckq B6.Cg-Ptpmt1^tm1Ckq	absent inner cell mass proliferation	J:178313
	disorganized embryonic tissue	J:178313
	embryonic growth retardation	J:178313
	embryonic lethality between implantation and somite formation, complete penetrance	J:178313
	increased embryonic tissue cell apoptosis	J:178313
Ptpmt1^tm2.1Ckq/Ptpmt1^tm2.1Ckq Cd19^tm1(cre)Cgn/Cd19⁺ involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL	normal hematopoietic system phenotype	J:194929
	normal immune system phenotype	J:194929
Ptpmt1^tm2.1Ckq/Ptpmt1^tm2.1Ckq Lyz2^tm1(cre)Ifo/Lyz2⁺ involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL	abnormal aerobic respiration	J:194929
	normal hematopoietic system phenotype	J:194929
	normal immune system phenotype	J:194929
Ptpmt1^tm2.1Ckq/Ptpmt1^tm2.1Ckq Tg(Lck-cre)1Cwi/0 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL	normal hematopoietic system phenotype	J:194929
	normal immune system phenotype	J:194929
Ptpmt1^tm2.1Ckq/Ptpmt1^tm2.1Ckq Tg(Mx1-cre)1Cgn/0 involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL	abnormal common lymphocyte progenitor cell morphology	J:194929
	abnormal hematopoietic stem cell physiology	J:194929
	anemia	J:194929
	decreased common myeloid progenitor cell number	J:194929
	normal hematopoietic system phenotype	J:194929
	increased hematopoietic stem cell number	J:194929
	pancytopenia	J:194929
	premature death	J:194929
Ptpmt1^tm2.1Ckq/Ptpmt1^tm2.1Ckq Tg(VAV1-cre)1Graf/0 involves: 129S6/SvEvTac * C57BL/6J * SJL	anemia	J:194929
	decreased bone marrow cell number	J:194929
	impaired hematopoiesis	J:194929
	increased hematopoietic stem cell number	J:194929
	pancytopenia	J:194929
	postnatal lethality, complete penetrance	J:194929
	small spleen	J:194929
	small thymus	J:194929

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