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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Sppl2a
signal peptide peptidase like 2A
MGI:1913802
34 phenotypes from 6 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Sppl2achompB/Sppl2achompB
involves: C57BL/6 		abnormal class switch recombination J:194595
abnormal humoral immune response J:194595
decreased activation-induced B cell apoptosis J:194595
decreased B cell proliferation J:194595
decreased follicular B cell number J:194595
decreased IgG1 level J:194595
decreased IgG2b level J:194595
decreased IgG3 level J:194595
decreased IgM level J:194595
decreased marginal zone B cell number J:194595
decreased mature B cell number J:194595
decreased myeloid dendritic cell number J:194595
decreased plasmacytoid dendritic cell number J:194595
decreased transitional stage T2 B cell number J:194595
normal immune system phenotype J:194595
Sppl2am1Anu/Sppl2am1Anu
involves: C57BL/6JAnu 		abnormal immunoglobulin level J:194663
abnormal mature B cell morphology J:194663
abnormal transitional stage B cell morphology J:194663
decreased IgG1 level J:194663
decreased IgM level J:194663
decreased marginal zone B cell number J:194663
decreased transitional stage T2 B cell number J:194663
decreased transitional stage T3 B cell number J:194663
normal hematopoietic system phenotype J:194663
Sppl2am1Btlr/Sppl2am1Btlr
C57BL/6J-Sppl2am1Btlr 		decreased IgG level J:236687
decreased response to antigen J:236687
Sppl2am2Btlr/Sppl2am2Btlr
C57BL/6J-Sppl2am2Btlr 		decreased IgG level J:236688
decreased IgM level J:236688
decreased response to antigen J:236688
Sppl2atm1Basc/Sppl2atm1Basc
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl 		abnormal B cell calcium ion homeostasis J:194664
abnormal B cell physiology J:194664
arrested B cell differentiation J:194664
decreased B cell number J:194664
decreased B-1 B cell number J:194664
decreased B-2 B cell number J:194664
decreased follicular B cell number J:194664
decreased IgA level J:194664
decreased IgG1 level J:194664
decreased IgG2a level J:194664
decreased IgG2b level J:194664
decreased IgG3 level J:194664
decreased IgM level J:194664
decreased marginal zone B cell number J:194664
decreased mature B cell number J:194664
decreased Peyer's patch number J:194664
decreased T cell number J:194664
decreased transitional stage T2 B cell number J:194664
small Peyer's patches J:194664
small spleen J:194664
Sppl2atm1Dgen/Sppl2atm1Dgen
B6.129P2-Sppl2atm1Dgen 		decreased B cell number J:194595
decreased B-1 B cell number J:194595
decreased follicular B cell number J:194595
decreased IgA level J:194595
decreased IgG1 level J:194595
decreased IgG2b level J:194595
decreased IgG3 level J:194595
decreased IgM level J:194595
decreased myeloid dendritic cell number J:194595
decreased transitional stage T2 B cell number J:194595
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory