Snrnp40 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Snrnp40
small nuclear ribonucleoprotein 40 (U5)
MGI:1913835

44 phenotypes from 4 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Snrnp40^em1(IMPC)Bay/Snrnp40^em1(IMPC)Bay C57BL/6N-Snrnp40^em1(IMPC)Bay/BayMmucd	preweaning lethality, complete penetrance	J:211773
Snrnp40^em1(IMPC)Bay/Snrnp40^em1(IMPC)Bay C57BL/6NJ-Snrnp40^em1(IMPC)Bay/Mmmh	abnormal egg cylinder morphology	J:279207
	disorganized extraembryonic tissue	J:279207
	embryonic growth retardation	J:279207
	embryonic lethality between implantation and placentation, complete penetrance	J:279207
	failure of primitive streak formation	J:279207
	failure to gastrulate	J:279207
Snrnp40^em1Btlr/Snrnp40^em1Btlr C57BL/6J-Snrnp40^em1Btlr	preweaning lethality, complete penetrance	J:282417
Snrnp40^em1Btlr/Snrnp40^em2Btlr C57BL/6J-Snrnp40^em1Btlr/Snrnp40^em2Btlr	preweaning lethality, complete penetrance	J:282417
Snrnp40^em1Btlr/Snrnp40^swp C57BL/6J-Snrnp40^em1Btlr/Snrnp40^swp	abnormal bone marrow cell morphology/development	J:282417
	abnormal CD4-positive, alpha-beta T cell physiology	J:282417
	abnormal CD8-positive, alpha-beta T cell physiology	J:282417
	abnormal thymus development	J:282417
	belly spot	J:282417
	decreased B cell number	J:282417
	decreased body weight	J:282417
	decreased CD4-positive, alpha-beta T cell number	J:282417
	decreased CD8-positive, alpha-beta T cell number	J:282417
	decreased common lymphocyte progenitor cell number	J:282417
	decreased DN1 thymic pro-T cell number	J:282417
	decreased DN4 thymocyte number	J:282417
	decreased erythrocyte cell number	J:282417
	decreased hematocrit	J:282417
	decreased hemoglobin content	J:282417
	decreased lymphocyte cell number	J:282417
	decreased monocyte cell number	J:282417
	decreased NK cell number	J:282417
	decreased T cell number	J:282417
	decreased T cell proliferation	J:282417
	normal immune system phenotype	J:282417
	impaired natural killer cell mediated cytotoxicity	J:282417
	increased central memory CD8 positive, alpha-beta T cell number	J:282417
	increased circulating interferon-beta level	J:282417
	increased circulating interferon-gamma level	J:282417
	increased circulating interleukin-6 level	J:282417
	increased circulating interleukin-12 level	J:282417
	increased circulating interleukin-17 level	J:282417
	increased circulating tumor necrosis factor level	J:282417
	increased effector memory CD8-positive, alpha-beta T cell number	J:282417
	increased red blood cell distribution width	J:282417
	increased susceptibility to viral infection	J:282417
	increased susceptibility to viral infection induced morbidity/mortality	J:282417
	small thymus	J:282417
	thrombocytosis	J:282417
	thymus hypoplasia	J:282417
	white spotting	J:282417
Snrnp40^em2Btlr/Snrnp40^em2Btlr C57BL/6J-Snrnp40^em2Btlr	preweaning lethality, complete penetrance	J:282417
Snrnp40^swp/Snrnp40^swp C57BL/6J-Snrnp40^swp	belly spot	J:282417
	decreased body weight	J:282417
	white spotting	J:282417

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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