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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lrrk2
leucine-rich repeat kinase 2
MGI:1913975
71 phenotypes from 20 alleles in 15 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Lrrk2tm1.1Cai/Lrrk2tm1.1Cai
involves: 129X1/SvJ * C57BL/6 		abnormal Golgi vesicle transport J:314451
abnormal vesicle-mediated transport J:314451
accumulation of giant lysosomes in kidney/renal tubule cells J:314451
microgliosis J:156512
normal nervous system phenotype J:156512
Lrrk2tm1.1Cai/Lrrk2tm1.1Cai
involves: 129X1/SvJ * C57BL/6J * FVB/N 		abnormal axon morphology J:154755
abnormal neurite morphology J:154755
Lrrk2tm1.1Dlbe/Lrrk2+
C57BL/6NTac-Lrrk2tm1.1Dlbe 		increased excitatory postsynaptic current frequency J:234639
Lrrk2tm1.1Dlbe/Lrrk2tm1.1Dlbe
C57BL/6NTac-Lrrk2tm1.1Dlbe 		abnormal dendritic spine morphology J:234639
abnormal excitatory postsynaptic current amplitude J:234639
abnormal excitatory postsynaptic currents J:234639
increased excitatory postsynaptic current frequency J:234639
Lrrk2tm1.1Hlme/Lrrk2+
involves: C57BL/6 * C57BL/6J 		abnormal dopamine level J:223350
abnormal mitochondrial crista morphology J:223350
abnormal mitochondrial morphology J:223350
abnormal mitochondrial shape J:223350
abnormal motor coordination/balance J:223350
abnormal synaptic dopamine release J:223350
tau protein deposits J:223350
Lrrk2tm1.1Hlme/Lrrk2tm1.1Hlme
involves: C57BL/6 * C57BL/6J 		abnormal dopamine level J:223350
abnormal lipid level J:223350
abnormal locomotor behavior J:223350
abnormal mitochondrial crista morphology J:223350
abnormal mitochondrial fission J:223350
abnormal mitochondrial morphology J:223350
abnormal mitochondrial shape J:223350
abnormal synaptic dopamine release J:223350
normal cardiovascular system phenotype J:223350
decreased mitochondrial number J:223350
dilated mitochondrion J:223350
enhanced coordination J:223350
increased locomotor activity J:223350
normal renal/urinary system phenotype J:223350
normal respiratory system phenotype J:223350
tau protein deposits J:223350
Lrrk2tm1.1Mjff/Lrrk2tm1.1Mjff
C57BL/6-Lrrk2tm1.1Mjff/J 		normal skeleton phenotype J:208677
Lrrk2tm1.1Npa/Lrrk2tm1.1Npa
either: B6.C-Lrrk2tm1.1Npa or (involves: BALB/c * C57BL/6J) 		normal behavior/neurological phenotype J:176679
normal cardiovascular system phenotype J:176679
increased systemic arterial diastolic blood pressure J:176679
normal nervous system phenotype J:176679
Lrrk2tm1.1Shn/Lrrk2tm1.1Shn
involves: 129 * C57BL/6 		abnormal action potential J:151944
abnormal adrenal gland secretion J:151944
abnormal Golgi vesicle transport J:314451
abnormal response/metabolism to endogenous compounds J:151944
decreased physiological sensitivity to xenobiotic J:151944
impaired behavioral response to addictive substance J:151944
impaired behavioral response to xenobiotic J:151944
normal nervous system phenotype J:151944
Lrrk2tm1.2Npa/Lrrk2tm1.2Npa
involves: BALB/c * C57BL/6J 		abnormal kidney morphology J:176679
abnormal proximal convoluted tubule morphology J:176679
abnormal type II pneumocyte morphology J:176679
normal behavior/neurological phenotype J:176679
normal cardiovascular system phenotype J:176679
dilated renal tubule J:176679
increased kidney weight J:176679
increased systemic arterial diastolic blood pressure J:176679
increased urine protein level J:176679
lipofuscinosis J:176679
normal nervous system phenotype J:176679
Lrrk2tm1Arte/Lrrk2tm1Arte
involves: C57BL/6N 		abnormal dendrite morphology J:206546
abnormal hippocampal mossy fiber morphology J:206546
increased neuronal precursor cell number J:206546
Lrrk2tm1Mjfa/Lrrk2tm1Mjfa
involves: C57BL/6 		abnormal axon extension J:172418
abnormal neurite morphology J:172418
Lrrk2tm1Tmd/Lrrk2tm1Tmd
involves: 129S/SvEv * C57BL/6 		alopecia J:157100
increased grooming behavior J:157100
preweaning lethality, incomplete penetrance J:157100
Lrrk2tm2.1Dlbe/Lrrk2tm2.1Dlbe
C57BL/6NTac-Lrrk2tm2.1Dlbe 		normal nervous system phenotype J:234639
Lrrk2tm2.1Npa/Lrrk2tm2.1Npa
involves: BALB/c * C57BL/6J 		abnormal kidney morphology J:176679
abnormal proximal convoluted tubule morphology J:176679
normal cardiovascular system phenotype J:176679
dilated renal tubule J:176679
increased kidney weight J:176679
lipofuscinosis J:176679
normal respiratory system phenotype J:176679
Lrrk2tm2.1Shn/Lrrk2tm2.1Shn
involves: 129 * C57BL/6 		abnormal autophagy J:160542
abnormal kidney morphology J:160542
decreased kidney weight J:160542
granular kidney J:160542
increased kidney apoptosis J:160542
increased renal glomerulus apoptosis J:160542
increased renal tubule apoptosis J:160542
kidney atrophy J:160542
kidney inflammation J:160542
lipofuscinosis J:160542
normal nervous system phenotype J:160542
small kidney J:160542
Lrrk2tm2Arte/Lrrk2tm2Arte
Not Specified 		no abnormal phenotype detected J:211935
Lrrk2tm2Mjfa/Lrrk2tm2Mjfa
Not Specified 		normal nervous system phenotype J:172418
Lrrk2tm3.1Mjfa/Lrrk2tm3.1Mjfa
involves: C57BL/6 		no abnormal phenotype detected J:101977
Lrrk2tm3.1Shn/Lrrk2tm3.1Shn
involves: 129 * C57BL/6 		abnormal kidney morphology J:160542
decreased kidney weight J:160542
granular kidney J:160542
kidney atrophy J:160542
normal nervous system phenotype J:160542
small kidney J:160542
Lrrk2tm4.1Arte/Lrrk2+
C57BL/6-Lrrk2tm4.1Arte/Tac 		abnormal brain interneuron morphology J:312767
abnormal dorsal striatum morphology J:312767
Tg(Lrrk2)6Yue/0
involves: C3H * C57BL/6 * C57BL/6J 		enhanced coordination J:157931
increased locomotor activity J:157931
increased neurotransmitter release J:157931
increased vertical activity J:157931
long stride length J:157931
normal nervous system phenotype J:157931
tau protein deposits J:157931
Tg(Lrrk2*G2019S)2Yue/0
involves: C3H * C57BL/6 * C57BL/6J 		abnormal locomotor coordination J:157931
abnormal neurotransmitter uptake J:157931
decreased dopamine level J:157931
decreased neurotransmitter release J:157931
normal nervous system phenotype J:157931
short stride length J:157931
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/19/2024
MGI 6.24 		The Jackson Laboratory