Foxp1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Foxp1
forkhead box P1
MGI:1914004

35 phenotypes from 5 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Foxp1^tm1.1Pwt/Foxp1^tm1.1Pwt Tg(Cd4-cre)1Cwi/0 involves: 129 * C57BL/6 * DBA/2	abnormal T cell activation	J:156832
	decreased CD4-positive, alpha-beta T cell number	J:156832
	decreased CD8-positive, alpha-beta T cell number	J:156832
	normal immune system phenotype	J:156832
	increased T cell apoptosis	J:156832
Foxp1^{tm1b(KOMP)Wtsi}/Foxp1⁺ C57BL/6N-Foxp1^{tm1b(KOMP)Wtsi}/J	hyperactivity	J:211773
	increased lean body mass	J:211773
Foxp1^{tm1b(KOMP)Wtsi}/Foxp1^{tm1b(KOMP)Wtsi} C57BL/6N-Foxp1^{tm1b(KOMP)Wtsi}/J	preweaning lethality, complete penetrance	J:211773
Foxp1^tm1Eem/Foxp1^tm1Eem involves: 129S6/SvEvTac * C57BL/6	abnormal heart development	J:93182
	conotruncal ridge hyperplasia	J:93182
	decreased heart rate	J:93182
	disorganized myocardium	J:93182
	double outlet right ventricle	J:93182
	hemorrhage	J:93182
	hydrops fetalis	J:93182
	increased atrioventricular cushion size	J:93182
	irregular heartbeat	J:93182
	lethality throughout fetal growth and development, incomplete penetrance	J:93182
	persistent truncus arteriosus	J:93182
	thin ventricle myocardium compact layer	J:93182
	ventricular septal defect	J:93182
Foxp1^tm1Rao/Foxp1^tm1Rao B6.129-Foxp1^tm1Rao	abnormal B cell differentiation	J:112644
	abnormal B cell physiology	J:112644
	arrested B cell differentiation	J:112644
	decreased mature B cell number	J:112644
	lethality throughout fetal growth and development, complete penetrance	J:112644
Foxp1^tm2.1Eem/Foxp1^tm2.1Eem Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ involves: 129 * C57BL/6 * SJL	abnormal heart development	J:163662
	abnormal sarcomere morphology	J:163662
	double outlet right ventricle	J:163662
	increased fetal cardiomyocyte proliferation	J:163662
	neonatal lethality, complete penetrance	J:163662
	thick interventricular septum	J:163662
	thick ventricular wall	J:163662
	ventricular septal defect	J:163662
Foxp1^tm2.1Eem/Foxp1^tm2.1Eem Tg(Tek-cre)1Ywa/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	abnormal cardiac outflow tract development	J:163662
	abnormal fetal cardiomyocyte proliferation	J:163662
	normal cardiovascular system phenotype	J:163662
	increased atrioventricular cushion size	J:163662
	lethality throughout fetal growth and development, complete penetrance	J:163662
	thin ventricular wall	J:163662
	ventricular septal defect	J:163662

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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