Rnf128 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rnf128
ring finger protein 128
MGI:1914139

30 phenotypes from 5 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rnf128^em1Tvg/Rnf128^em1Tvg BALB/cJ-Rnf128^em1Tvg	decreased tumor incidence following infection	J:329456
Rnf128^{tm1.1(KOMP)Vlcg}/Y C57BL/6N-Rnf128^{tm1.1(KOMP)Vlcg}/Ccpcz	abnormal urinary bladder morphology	J:211773
	enlarged urinary bladder	J:211773
	increased effector memory T-helper cell number	J:211773
Rnf128^tm1.1Flv/Y involves: 129S6/SvEvTac * C57BL/6	abnormal CD4-positive, alpha-beta T cell physiology	J:153216
	abnormal peripheral T cell anergy	J:153216
	increased circulating interleukin-2 level	J:153216
	increased interferon-gamma secretion	J:153216
	increased T cell proliferation	J:153216
Rnf128^tm1.1Flv/Rnf128^tm1.1Flv involves: 129S6/SvEvTac * C57BL/6	abnormal CD4-positive, alpha-beta T cell physiology	J:153216
	abnormal peripheral T cell anergy	J:153216
	increased circulating interleukin-2 level	J:153216
	increased interferon-gamma secretion	J:153216
	increased T cell proliferation	J:153216
Rnf128^tm1.2Cmse/Rnf128^tm1.2Cmse involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal macrophage physiology	J:245025
	normal homeostasis/metabolism phenotype	J:245025
Rnf128^tm1Cdon/Rnf128⁺ involves: 129 * C57BL/6	increased susceptibility to experimental autoimmune encephalomyelitis	J:160681
Rnf128^tm1Cdon/Rnf128^tm1Cdon involves: 129 * C57BL/6	abnormal immune tolerance	J:160681
	abnormal interleukin secretion	J:160681
	abnormal regulatory T cell physiology	J:160681
	CNS inflammation	J:160681
	decreased interleukin-4 secretion	J:160681
	decreased interleukin-5 secretion	J:160681
	decreased interleukin-13 secretion	J:160681
	enlarged mesenteric lymph nodes	J:160681
	enlarged spleen	J:160681
	increased anti-double stranded DNA antibody level	J:160681
	increased IgG1 level	J:160681
	increased IgM level	J:160681
	increased interferon-gamma secretion	J:160681
	increased interleukin-2 secretion	J:160681
	increased interleukin-4 secretion	J:160681
	increased interleukin-17 secretion	J:160681
	increased interleukin-21 secretion	J:160681
	increased splenocyte proliferation	J:160681
	increased susceptibility to experimental autoimmune encephalomyelitis	J:160681
	lung inflammation	J:160681
Rnf128^tm1Cdon/Rnf128^tm1Cdon involves: C57BL/6	increased anti-double stranded DNA antibody level	J:160681
	increased interferon-gamma secretion	J:160681
	increased interleukin-2 secretion	J:160681
	increased interleukin-17 secretion	J:160681
	increased T cell proliferation	J:160681

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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