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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pole4
polymerase (DNA-directed), epsilon 4 (p12 subunit)
MGI:1914229
62 phenotypes from 1 allele in 2 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Pole4tm1(KOMP)Vlcg/Pole4tm1(KOMP)Vlcg
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac * FVB/N 		abnormal B cell differentiation J:261973
abnormal cell cycle J:261973
abnormal craniofacial morphology J:261973
abnormal DNA replication J:261973
abnormal fourth ventricle morphology J:261973
abnormal gait J:261973
abnormal mesenteric lymph node morphology J:261973
abnormal pelvic girdle bone morphology J:261973
abnormal roof plate morphology J:261973
abnormal spleen B cell follicle morphology J:261973
abnormal T cell differentiation J:261973
abnormal thymus morphology J:261973
absent thymus cortex J:261973
anemia J:261973
arrested B cell differentiation J:261973
ataxia J:261973
athymia J:261973
belly spot J:261973
caudal vertebral fusion J:261973
chromosomal instability J:261973
curly tail J:261973
decreased B cell number J:261973
decreased body length J:261973
decreased body weight J:261973
decreased brain weight J:261973
decreased embryo size J:261973
decreased embryo weight J:261973
decreased fetal size J:261973
decreased fetal weight J:261973
decreased fibroblast proliferation J:261973
decreased hematopoietic stem cell number J:261973
decreased leukocyte cell number J:261973
decreased litter size J:261973
decreased lymphocyte cell number J:261973
decreased male germ cell number J:261973
decreased single-positive T cell number J:261973
decreased spleen weight J:261973
impaired coordination J:261973
increased cellular sensitivity to hydroxyurea J:261973
increased double-negative T cell number J:261973
increased embryonic tissue cell apoptosis J:261973
increased forebrain apoptosis J:261973
increased granulocyte number J:261973
increased hematopoietic stem cell number J:261973
increased lymphoma incidence J:261973
increased monocyte cell number J:261973
increased T cell derived lymphoma incidence J:261973
induced chromosome breakage J:261973
kinked tail J:261973
lethality throughout fetal growth and development, incomplete penetrance J:261973
postnatal growth retardation J:261973
prenatal growth retardation J:261973
prominent forehead J:261973
reduced cerebellar foliation J:261973
reduced fertility J:261973
short mandible J:261973
short tibia J:261973
small cerebellum J:261973
small spleen J:261973
thrombocytosis J:261973
Pole4tm1(KOMP)Vlcg/Pole4tm1(KOMP)Vlcg
involves: C57BL/6J * C57BL/6NTac 		abnormal DNA replication J:261973
abnormal embryo development J:261973
embryonic lethality during organogenesis, incomplete penetrance J:261973
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory