Med19 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Med19
mediator complex subunit 19
MGI:1914234

32 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Med19^{tm1a(EUCOMM)Wtsi}/Med19^{tm1a(EUCOMM)Wtsi} C57BL/6N-Med19^{tm1a(EUCOMM)Wtsi}/Wtsi	preweaning lethality, complete penetrance	J:211773
Med19^{tm1c(EUCOMM)Wtsi}/Med19^{tm1c(EUCOMM)Wtsi} Tg(Adipoq-cre)1Evdr/0 involves: C57BL/6J * C57BL/6N * FVB/NJ	abnormal brown adipose tissue physiology	J:298822
	abnormal interscapular fat pad morphology	J:298822
	abnormal liver physiology	J:298822
	abnormal white adipose tissue morphology	J:298822
	abnormal white adipose tissue physiology	J:298822
	abnormal white fat cell size	J:298822
	decreased body fat mass	J:298822
	decreased gonadal fat pad weight	J:298822
	decreased inguinal fat pad weight	J:298822
	decreased mesenteric fat pad weight	J:298822
	decreased retroperitoneal fat pad weight	J:298822
	decreased subcutaneous adipose tissue amount	J:298822
	decreased white adipose tissue mass	J:298822
	decreased white fat cell number	J:298822
	enlarged liver	J:298822
	hepatic steatosis	J:298822
	hyperglycemia	J:298822
	impaired glucose tolerance	J:298822
	increased body weight	J:298822
	increased circulating insulin level	J:298822
	increased lean body mass	J:298822
	increased liver triglyceride level	J:298822
	increased liver weight	J:298822
	insulin resistance	J:298822
	pale liver	J:298822
	whitened brown adipose tissue morphology	J:298822
Med19^{tm1c(EUCOMM)Wtsi}/Med19^{tm1c(EUCOMM)Wtsi} Tg(Adipoq-icre/ERT2)1Soff/0 involves: C57BL/6J * C57BL/6N	abnormal white fat cell size	J:298822
	decreased gonadal fat pad weight	J:298822
	decreased inguinal fat pad weight	J:298822
	decreased white adipose tissue mass	J:298822
	decreased white fat cell number	J:298822
	normal growth/size/body region phenotype	J:298822
	impaired lipolysis	J:298822
	increased white adipose tissue apoptosis	J:298822
	lipodystrophy	J:298822
	white adipose tissue inflammation	J:298822
	whitened brown adipose tissue morphology	J:298822

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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