Riok2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Riok2
RIO kinase 2
MGI:1914295

28 phenotypes from 2 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Riok2^{tm1b(KOMP)Wtsi}/Riok2⁺ C57BL/6N-Riok2^{tm1b(KOMP)Wtsi}/Tcp	increased circulating alanine transaminase level	J:211773
	increased circulating aspartate transaminase level	J:211773
	increased circulating bilirubin level	J:211773
Riok2^{tm1b(KOMP)Wtsi}/Riok2^{tm1b(KOMP)Wtsi} C57BL/6N-Riok2^{tm1b(KOMP)Wtsi}/Tcp	embryonic lethality prior to organogenesis	J:211773
	prenatal lethality prior to heart atrial septation	J:211773
	preweaning lethality, incomplete penetrance	J:211773
Riok2^{tm1c(KOMP)Wtsi}/Riok2⁺ Tg(Cd4-cre)1Cwi/0 involves: C57BL/6 * C57BL/6N * DBA/2	anemia	J:305794
	decreased erythrocyte cell number	J:305794
	decreased hematocrit	J:305794
	decreased hemoglobin content	J:305794
Riok2^{tm1c(KOMP)Wtsi}/Riok2⁺ Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ involves: C57BL/6N * C57BL/10 * CBA/Ca	abnormal bone marrow cell physiology	J:305794
	abnormal CD4-positive, alpha beta T cell morphology	J:305794
	abnormal CD4-positive, alpha-beta T cell physiology	J:305794
	abnormal circulating interleukin level	J:305794
	abnormal erythropoiesis	J:305794
	abnormal hematopoietic system physiology	J:305794
	abnormal immune system morphology	J:305794
	abnormal interleukin secretion	J:305794
	anemia	J:305794
	decreased erythrocyte cell number	J:305794
	decreased erythroid progenitor cell number	J:305794
	decreased hematocrit	J:305794
	decreased hemoglobin content	J:305794
	decreased neutrophil cell number	J:305794
	increased granulocyte monocyte progenitor cell number	J:305794
	increased hematopoietic stem cell number	J:305794
	increased monocyte cell number	J:305794
	increased myeloid cell number	J:305794
	increased NK T cell number	J:305794
	increased physiological sensitivity to xenobiotic	J:305794
	increased susceptibility to xenobiotic induced morbidity/mortality	J:305794
Riok2^{tm1c(KOMP)Wtsi}/Riok2⁺ Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺ involves: 129S4/SvJae * C57BL/6 * C57BL/6N	anemia	J:305794
	decreased erythrocyte cell number	J:305794
	decreased hematocrit	J:305794
	decreased hemoglobin content	J:305794
Riok2^{tm1c(KOMP)Wtsi}/Riok2^{tm1c(KOMP)Wtsi} Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ involves: C57BL/6N * C57BL/10 * CBA/Ca	prenatal lethality, complete penetrance	J:305794

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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