Rnaseh2b Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rnaseh2b
ribonuclease H2, subunit B
MGI:1914403

20 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rnaseh2b^em1Anu/Rnaseh2b^em1Anu C57BL/6NCrl-Rnaseh2b^em1Anu	embryonic lethality, complete penetrance	J:324448
Rnaseh2b^{tm1a(EUCOMM)Wtsi}/Rnaseh2b^{tm1a(EUCOMM)Wtsi} involves: C57BL/6N	abnormal blood vessel morphology	J:186986
	decreased birth body size	J:186986
	decreased cell proliferation	J:186180
	decreased embryo size	J:186180
	decreased fibroblast proliferation	J:186986
	edema	J:186986
	embryonic growth retardation	J:186180
	hemorrhage	J:186986
	liver hypoplasia	J:186986
	perinatal lethality, complete penetrance	J:186986
	preweaning lethality	J:186180
	thymus hypoplasia	J:186986
Rnaseh2b^{tm1c(EUCOMM)Wtsi}/Rnaseh2b^{tm1c(EUCOMM)Wtsi} Cd19^tm1(cre)Cgn/Cd19⁺ involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * SJL	decreased B cell proliferation	J:186986
	normal immune system phenotype	J:186986
Rnaseh2b^{tm1c(EUCOMM)Wtsi}/Rnaseh2b^{tm1c(EUCOMM)Wtsi} Tg(Pgk1-cre)1Lni/0 involves: BALB/c * C57BL/6 * C57BL/6N * SJL	embryonic lethality during organogenesis, complete penetrance	J:186986
Rnaseh2b^tm1Hgu/Rnaseh2b^tm1Hgu involves: 129P2/OlaHsd * C57BL/6J	abnormal allantois morphology	J:186180
	abnormal cell morphology	J:186180
	caudal body truncation	J:186180
	decreased embryo size	J:186180
	embryonic growth retardation	J:186180
	impaired somite development	J:186180
	preweaning lethality	J:186180

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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