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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cul4a
cullin 4A
MGI:1914487
59 phenotypes from 6 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cul4a/Pcid2tm2Ktc/Cul4a/Pcid2tm2Ktc
Tg(Mx1-cre)1Cgn/0
involves: 129S/SvEv * C57BL/6 * CBA * FVB/N 		abnormal definitive hematopoiesis J:138468
abnormal enterocyte morphology J:138468
abnormal leukocyte morphology J:138468
abnormal small intestine crypts of Lieberkuhn morphology J:138468
abnormal spleen capsule morphology J:138468
abnormal spleen morphology J:138468
decreased bone marrow cell number J:138468
decreased hematocrit J:138468
decreased hematopoietic stem cell number J:138468
decreased lymphocyte cell number J:138468
decreased monocyte cell number J:138468
decreased neutrophil cell number J:138468
decreased spleen red pulp amount J:138468
decreased spleen weight J:138468
decreased spleen white pulp amount J:138468
impaired hematopoiesis J:138468
increased enterocyte apoptosis J:138468
premature death J:138468
small intestinal villus atrophy J:138468
small thymus J:138468
spleen hypoplasia J:138468
thrombocytopenia J:138468
Cul4atm1.1Pra/Cul4atm1.1Pra
involves: C57BL/6NTac 		abnormal cell cycle checkpoint function J:172043
abnormal centrosome morphology J:172043
abnormal DNA replication J:172043
chromosomal instability J:172043
decreased fibroblast proliferation J:172043
increased cellular sensitivity to ultraviolet irradiation J:172043
Cul4atm1.1Pra/Cul4atm1.1Pra
Not Specified 		normal reproductive system phenotype J:171470
Cul4atm1.1Pra/Cul4atm1.1Pra
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: C57BL/6 * C57BL/6NTac * DBA 		decreased body weight J:172043
decreased hepatocyte proliferation J:172043
increased susceptibility to injury J:172043
Cul4atm1.1Pz/Cul4atm1.1Pz
Tg(KRT14-cre/ERT)20Efu/?
involves: C57BL/6 * CD-1 		decreased incidence of tumors by UV induction J:150427
Cul4atm1.2Pra/Cul4atm1.2Pra
Not Specified 		abnormal double-strand DNA break repair J:171470
abnormal male meiosis J:171470
abnormal sperm flagellum morphology J:171470
abnormal sperm head morphology J:171470
abnormal spermatid morphology J:171470
abnormal spermatocyte morphology J:171470
abnormal spermatogenesis J:171470
asthenozoospermia J:171470
azoospermia J:171470
decreased litter size J:171470
decreased testis weight J:171470
increased male germ cell apoptosis J:171470
male infertility J:171470
multinucleated giant male germ cells J:171470
oligozoospermia J:171470
reduced female fertility J:171470
small epididymis J:171470
small testis J:171470
Cul4atm1.2Pz/Cul4atm1.2Pz
B6.Cg-Cul4atm1.2Pz 		abnormal cell cycle checkpoint function J:150427
abnormal DNA repair J:150427
Cul4atm1b(EUCOMM)Hmgu/Cul4atm1b(EUCOMM)Hmgu
C57BL/6N-Cul4atm1b(EUCOMM)Hmgu/Ccpcz 		abnormal retina morphology J:211773
abnormal testis morphology J:211773
decreased circulating chloride level J:211773
decreased mean platelet volume J:211773
enhanced cued conditioning behavior J:211773
increased circulating potassium level J:211773
increased fasting circulating glucose level J:211773
male infertility J:211773
small testis J:211773
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory