Smc6 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Smc6
structural maintenance of chromosomes 6
MGI:1914491

25 phenotypes from 4 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Smc6^{Gt(RRT274)Byg}/Smc6^{Gt(RRT274)Byg} involves: 129P2/OlaHsd * C57BL/6	decreased embryo size	J:220422
	embryonic growth retardation	J:220422
	embryonic lethality during organogenesis, complete penetrance	J:220422
Smc6^tm1.1Arln/Smc6^tm1.1Arln involves: 129P2/OlaHsd * C57BL/6 * FVB	abnormal motor coordination/balance	J:220422
	decreased body mass index	J:220422
	decreased circulating HDL cholesterol level	J:220422
	decreased IgG2b level	J:220422
	decreased total body fat amount	J:220422
	normal growth/size/body region phenotype	J:220422
	increased circulating calcium level	J:220422
	increased circulating glucose level	J:220422
	increased leukocyte cell number	J:220422
	increased thermal nociceptive threshold	J:220422
	macrocytosis	J:220422
	normal mortality/aging	J:220422
	thrombocytosis	J:220422
Smc6^tm1Arln/Smc6^tm1Arln involves: 129P2/OlaHsd * C57BL/6	decreased body size	J:220422
	decreased body weight	J:220422
	decreased fetal size	J:220422
	decreased litter size	J:220422
	preweaning lethality, incomplete penetrance	J:220422
Smc6^{tm1b(EUCOMM)Hmgu}/Smc6⁺ C57BL/6N-Smc6^{tm1b(EUCOMM)Hmgu}/Ieg	decreased lean body mass	J:211773
	increased circulating serum albumin level	J:211773
	increased total body fat amount	J:211773
Smc6^{tm1b(EUCOMM)Hmgu}/Smc6^{tm1b(EUCOMM)Hmgu} C57BL/6N-Smc6^{tm1b(EUCOMM)Hmgu}/Ieg	preweaning lethality, complete penetrance	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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