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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Elp1
elongator complex protein 1
MGI:1914544
102 phenotypes from 6 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Elp1Gt(BGB184)Byg/Elp1Gt(BGB184)Byg
B6.129P2-Gt(BGB184)Byg 		abnormal brain development J:145561
abnormal embryonic erythropoiesis J:145561
abnormal embryonic tissue morphology J:145561
abnormal vascular development J:145561
abnormal vitelline vasculature morphology J:145561
absent limb buds J:145561
absent pharyngeal arches J:145561
absent visceral yolk sac blood islands J:145561
decreased embryo size J:145561
embryonic growth arrest J:145561
embryonic lethality during organogenesis, complete penetrance J:145561
incomplete embryo turning J:145561
incomplete rostral neuropore closure J:145561
small placenta J:145561
Elp1tm1.1Id/Elp1tm1.1Id
involves: 129S1/Sv * C57BL/6 * CBA 		abnormal brain development J:178070
abnormal cardiac outflow tract development J:178070
abnormal cardinal vein morphology J:178070
abnormal dorsal aorta morphology J:178070
abnormal forebrain development J:178070
abnormal heart development J:178070
abnormal heart looping J:178070
abnormal telencephalon development J:178070
abnormal vitelline vasculature morphology J:178070
absent atrioventricular cushions J:178070
absent heartbeat J:178070
absent lamina terminalis J:178070
absent optic vesicle J:178070
absent second pharyngeal arch J:178070
decreased embryo size J:178070
distended pericardium J:178070
embryonic growth retardation J:178070
embryonic lethality during organogenesis, complete penetrance J:178070
pallor J:178070
pericardial effusion J:178070
Elp1tm1.1Id/Elp1tm1.2Id
involves: 129S1/Sv * C57BL/6 * C57BL/6J * CBA 		abnormal autopod morphology J:188923
abnormal dorsal root ganglion morphology J:188923
abnormal fungiform papillae morphology J:188923
abnormal gait J:188923
abnormal intestine physiology J:188923
abnormal locomotor coordination J:188923
abnormal lumbar dorsal root ganglion morphology J:188923
abnormal optic nerve innervation J:188923
abnormal placenta development J:188923
abnormal posture J:188923
abnormal sensory ganglion morphology J:188923
abnormal skeleton morphology J:188923
abnormal spongiotrophoblast layer morphology J:188923
abnormal stellate ganglion morphology J:188923
abnormal suckling behavior J:188923
abnormal superior cervical ganglion morphology J:188923
abnormal sympathetic ganglion morphology J:188923
absent gastric milk in neonates J:188923
ataxia J:188923
audiogenic seizures J:188923
blepharoptosis J:188923
conjunctivitis J:188923
decreased birth body size J:188923
decreased birth weight J:188923
decreased body length J:188923
decreased body weight J:188923
decreased survivor rate J:188923
decreased total body fat amount J:188923
distended urinary bladder J:188923
environmentally induced seizures J:188923
excessive scratching J:188923
fetal growth retardation J:188923
hydronephrosis J:188923
increased grooming behavior J:188923
increased thermal nociceptive threshold J:188923
kyphoscoliosis J:188923
kyphosis J:188923
limb grasping J:188923
neurogenic bladder J:188923
optic neuropathy J:188923
postnatal lethality, incomplete penetrance J:188923
slow postnatal weight gain J:188923
small placenta J:188923
Elp1tm1.2Id/Elp1tm1.2Id
involves: 129S1/Sv * C57BL/6 * C57BL/6J * CBA 		abnormal autonomic nervous system physiology J:188923
abnormal dorsal root ganglion morphology J:188923
abnormal fungiform papillae morphology J:188923
abnormal innervation pattern to muscle J:188923
abnormal intestine physiology J:188923
abnormal lumbar dorsal root ganglion morphology J:188923
abnormal muscle spindle morphology J:188923
abnormal optic disk morphology J:188923
abnormal optic nerve innervation J:188923
abnormal placenta development J:188923
abnormal posture J:188923
abnormal sensory ganglion morphology J:188923
abnormal skeleton morphology J:188923
abnormal stellate ganglion morphology J:188923
abnormal suckling behavior J:188923
abnormal superior cervical ganglion morphology J:188923
abnormal sympathetic ganglion morphology J:188923
ataxia J:188923
audiogenic seizures J:188923
blepharoptosis J:188923
conjunctivitis J:188923
decreased birth body size J:188923
decreased body length J:188923
decreased body size J:188923
decreased body weight J:188923
decreased survivor rate J:188923
decreased total body fat amount J:188923
distended urinary bladder J:188923
environmentally induced seizures J:188923
excessive scratching J:188923
fetal growth retardation J:188923
hydronephrosis J:188923
increased grooming behavior J:188923
increased thermal nociceptive threshold J:188923
kyphoscoliosis J:188923
kyphosis J:188923
limb grasping J:188923
neurogenic bladder J:188923
optic nerve atrophy J:188923
optic neuropathy J:188923
perinatal lethality, incomplete penetrance J:188923
postnatal growth retardation J:188923
slow postnatal weight gain J:188923
thin retina ganglion layer J:188923
Elp1tm1a(KOMP)Wtsi/Elp1tm1a(KOMP)Wtsi
B6Brd;B6Dnk;B6N-Tyrc-Brd Elp1tm1a(KOMP)Wtsi/Wtsi 		preweaning lethality, complete penetrance J:211773
Elp1tm1c(KOMP)Wtsi/Elp1tm1c(KOMP)Wtsi
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: C57BL/6J * C57BL/6N * CBA/J 		abnormal dorsal root ganglion morphology J:202989
abnormal facial morphology J:202989
abnormal nervous system physiology J:202989
abnormal neuron differentiation J:202989
abnormal sensory neuron innervation pattern J:202989
abnormal submandibular gland morphology J:202989
abnormal superior cervical ganglion morphology J:202989
decreased fetal size J:202989
decreased neuron number J:202989
decreased sensory neuron number J:202989
increased neuron apoptosis J:202989
increased neuron number J:202989
mandibular retrognathia J:202989
neonatal lethality, complete penetrance J:202989
Elp1tm1c(KOMP)Wtsi/Elp1tm1c(KOMP)Wtsi
Tg(Ddx4-cre)1Dcas/0
involves: 129 * C57BL/6N * FVB 		abnormal chromosomal synapsis J:200015
abnormal dosage compensation, by inactivation of X chromosome J:200015
abnormal double-strand DNA break repair J:200015
abnormal X-Y chromosome synapsis during male meiosis J:200015
arrest of male meiosis J:200015
azoospermia J:200015
male infertility J:200015
small testis J:200015
Elp1tm1Id/Elp1tm1Id
involves: 129S1/Sv * C57BL/6 		abnormal brain development J:178070
abnormal cardiac outflow tract development J:178070
abnormal cardinal vein morphology J:178070
abnormal dorsal aorta morphology J:178070
abnormal forebrain development J:178070
abnormal heart development J:178070
abnormal heart looping J:178070
abnormal telencephalon development J:178070
abnormal vitelline vasculature morphology J:178070
absent atrioventricular cushions J:178070
absent heartbeat J:178070
absent lamina terminalis J:178070
absent optic vesicle J:178070
absent second pharyngeal arch J:178070
decreased embryo size J:178070
distended pericardium J:178070
embryonic growth retardation J:178070
embryonic lethality during organogenesis, complete penetrance J:178070
pallor J:178070
pericardial effusion J:178070
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory