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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Abhd5
abhydrolase domain containing 5
MGI:1914719
62 phenotypes from 5 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Abhd5tm1.1Lqyu/Abhd5tm1.1Lqyu
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * DBA 		abnormal hepatocyte morphology J:199570
abnormal lipid level J:199570
abnormal liver morphology J:199570
abnormal liver physiology J:199570
abnormal phospholipid level J:199570
decreased fatty acid oxidation J:199570
decreased triglyceride lipase activity J:199570
enlarged liver J:199570
hepatic steatosis J:199570
normal homeostasis/metabolism phenotype J:199570
increased circulating alanine transaminase level J:199570
increased circulating aspartate transaminase level J:199570
increased liver cholesterol level J:199570
increased liver free fatty acids level J:199570
increased liver triglyceride level J:199570
increased liver weight J:199570
liver fibrosis J:199570
liver inflammation J:199570
macrovesicular hepatic steatosis J:199570
microvesicular hepatic steatosis J:199570
oxidative stress J:199570
pale liver J:199570
Abhd5tm1.1Rze/Abhd5tm1.1Rze
involves: 129P2/OlaHsd * C57BL/6 		abnormal granulocyte morphology J:160725
abnormal keratinocyte differentiation J:160725
abnormal lipid homeostasis J:160725
abnormal lipid level J:160725
abnormal skin development J:160725
abnormal skin physiology J:160725
decreased birth body size J:160725
decreased birth weight J:160725
decreased body length J:160725
decreased circulating glucose level J:160725
decreased circulating triglyceride level J:160725
decreased fatty acids level J:160725
decreased triglyceride lipase activity J:160725
epidermis stratum spinosum hyperplasia J:160725
hepatic steatosis J:160725
hyperkeratosis J:160725
impaired lipolysis J:160725
impaired skin barrier function J:160725
increased liver triglyceride level J:160725
increased triglyceride level J:160725
neonatal lethality J:160725
Abhd5tm1a(KOMP)Wtsi/Abhd5tm1a(KOMP)Wtsi
B6JTyr;B6N-Abhd5tm1a(KOMP)Wtsi/Wtsi 		abnormal maxilla morphology J:165965
decreased body weight J:165965, J:175295
Abhd5tm1a(KOMP)Wtsi/Abhd5tm1a(KOMP)Wtsi
involves: C57BL/6 * C57BL/6N 		abnormal Sertoli cell morphology J:213427
decreased bone trabecula number J:213427
increased trabecular bone thickness J:213427
Abhd5tm1Murm/Abhd5tm1Murm
B6.129S-Abhd5tm1Murm 		abnormal ceramide level J:240682
increased triglyceride level J:240682
Abhd5tm1Rze/Abhd5tm1Rze
Tg(Ckmm-cre)5Khn/0
involves: 129P2/OlaHsd * C57BL/6 * FVB 		abnormal glucose homeostasis J:197835
abnormal heart left ventricle morphology J:197835
abnormal lipid homeostasis J:197835
decreased circulating free fatty acids level J:197835
decreased circulating glucose level J:197835
decreased circulating insulin level J:197835
decreased circulating triglyceride level J:197835
decreased heart left ventricle muscle contractility J:197835
decreased lipoprotein lipase activity J:197835
decreased liver triglyceride level J:197835
decreased oxygen consumption J:197835
normal homeostasis/metabolism phenotype J:197835
impaired lipolysis J:197835
improved glucose tolerance J:197835
increased cardiac muscle cell glucose uptake J:197835
increased cardiac muscle triglyceride level J:197835
increased heart left ventricle weight J:197835
increased heart weight J:197835
increased respiratory quotient J:197835
increased skeletal muscle triglyceride level J:197835
myocardium steatosis J:197835
premature death J:197835
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory