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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Abcg8
ATP binding cassette subfamily G member 8
MGI:1914720
47 phenotypes from 2 alleles in 2 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Abcg8tm1b(KOMP)Wtsi/Abcg8tm1b(KOMP)Wtsi
C57BL/6N-Abcg8tm1b(KOMP)Wtsi/Ccpcz 		abnormal cholesterol homeostasis J:211773
abnormal heart left ventricle morphology J:211773
abnormal lens morphology J:211773
abnormal liver morphology J:211773
abnormal retina blood vessel morphology J:211773
abnormal spleen morphology J:211773
cataract J:211773
decreased B-2 B cell number J:211773
decreased CD4-negative NK T cell number J:211773
decreased CD4-positive, alpha-beta T cell number J:211773
decreased CD8-positive, alpha-beta T cell number J:211773
decreased circulating iron level J:211773
decreased circulating serum albumin level J:211773
decreased circulating sodium level J:211773
decreased hemoglobin content J:211773
decreased lung compliance J:211773
decreased mean corpuscular hemoglobin J:211773
decreased mean corpuscular hemoglobin concentration J:211773
decreased mean corpuscular volume J:211773
decreased memory-marker CD4-negative NK T cell number J:211773
decreased NK T cell number J:211773
decreased T cell number J:211773
enlarged liver J:211773
enlarged spleen J:211773
female infertility J:211773
immune system phenotype J:211773
impaired righting response J:211773
increased cardiac muscle contractility J:211773
increased circulating alanine transaminase level J:211773
increased circulating alkaline phosphatase level J:211773
increased circulating aspartate transaminase level J:211773
increased circulating cholesterol level J:211773
increased circulating creatinine level J:211773
increased circulating potassium level J:211773
increased circulating triglyceride level J:211773
increased lung elastance J:211773
increased mean platelet volume J:211773
increased red blood cell distribution width J:211773
increased spleen weight J:211773
male infertility J:211773
Abcg8tm1Elk/Abcg8+
involves: 129S6/SvEvTac * C57BL/6J 		abnormal hepatobiliary system physiology J:94759
decreased circulating cholesterol level J:94759
Abcg8tm1Elk/Abcg8tm1Elk
involves: 129S6/SvEvTac * C57BL/6J 		abnormal hepatobiliary system physiology J:94759
decreased cholesterol level J:94759
decreased circulating cholesterol level J:94759
decreased fat cell size J:192806
decreased white adipose tissue amount J:192806
female infertility J:192806
increased circulating free fatty acids level J:192806
increased circulating phytosterol level J:94759
increased circulating triglyceride level J:94759
male infertility J:192806
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory