Slc39a8 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Slc39a8
solute carrier family 39 (metal ion transporter), member 8
MGI:1914797

31 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Slc39a8^em1Xijl/Slc39a8^em1Xijl involves: C57BL/6J	normal behavior/neurological phenotype	J:342738
	decreased brain zinc level	J:342738
	decreased dendritic spine density	J:342738
	decreased locomotor activity	J:342738
	normal growth/size/body region phenotype	J:342738
	normal homeostasis/metabolism phenotype	J:342738
	increased circulating zinc level	J:342738
	normal nervous system phenotype	J:342738
Slc39a8^tm1.1Brvo/Slc39a8^tm1.1Brvo involves: C57BL/6	abnormal homeostasis	J:341571
	normal cardiovascular system phenotype	J:341571
	decreased circulating glucose level	J:341571
	normal homeostasis/metabolism phenotype	J:341571
	hypotension	J:341571
	increased circulating glucose level	J:341571
	increased circulating insulin level	J:341571
	increased circulating phosphate level	J:341571
	increased insulin secretion	J:341571
	increased urine glucose level	J:341571
	insulin resistance	J:341571
	normal skeleton phenotype	J:341571
Slc39a8^tm1.2Mrl/Slc39a8^tm1.2Mrl B6(Cg)-Slc39a8^tm1.2Mrl	abnormal heart left ventricle morphology	J:258360
	abnormal heart morphology	J:258360
	abnormal myocardial trabeculae morphology	J:258360
	abnormal zinc level	J:258360
	edema	J:258360
	increased fetal cardiomyocyte proliferation	J:258360
	lethality throughout fetal growth and development, complete penetrance	J:258360
	thin myocardium compact layer	J:258360
	ventricular septal defect	J:258360
Slc39a8^{tm1b(EUCOMM)Wtsi}/Slc39a8⁺ C57BL/6N-Slc39a8^{tm1b(EUCOMM)Wtsi}/Cnrm	abnormal retina morphology	J:211773
	increased circulating triglyceride level	J:211773
Slc39a8^{tm1b(EUCOMM)Wtsi}/Slc39a8^{tm1b(EUCOMM)Wtsi} C57BL/6N-Slc39a8^{tm1b(EUCOMM)Wtsi}/Cnrm	preweaning lethality, complete penetrance	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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