Sdhb Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sdhb
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
MGI:1914930

18 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sdhb^tm1.1Ics/Sdhb^tm1.1Ics Tg(KLK3-cre)D4Trp/0 involves: 129S2/SvPas * FVB	no abnormal phenotype detected	J:236514
Sdhb^tm1.1Ics/Sdhb^tm1.1Ics Tg(Th-cre)12Mrub/0 involves: 129S2/SvPas * C57BL/6 * CBA	no abnormal phenotype detected	J:236514
Sdhb^tm1.2Ics/Sdhb^tm1.2Ics involves: 129S2/SvPas * BALB/c * C57BL/6	embryonic lethality, complete penetrance	J:236514
Sdhb^{tm1b(EUCOMM)Hmgu}/Sdhb⁺ C57BL/6N-Sdhb^{tm1b(EUCOMM)Hmgu}/Ieg	abnormal kidney morphology	J:211773
	decreased locomotor activity	J:211773
	decreased mean corpuscular hemoglobin concentration	J:211773
	decreased neutrophil cell number	J:211773
	increased fasting circulating glucose level	J:211773
Sdhb^{tm1b(EUCOMM)Hmgu}/Sdhb^{tm1b(EUCOMM)Hmgu} C57BL/6N-Sdhb^{tm1b(EUCOMM)Hmgu}/Ieg	preweaning lethality, complete penetrance	J:211773
Sdhb^{tm1c(EUCOMM)Hmgu}/Sdhb^{tm1c(EUCOMM)Hmgu} Tg(Ins2-cre)23Herr/0 involves: C57BL/6J * C57BL/6N * CBA/J	abnormal cellular respiration	J:326592
	abnormal endocrine pancreas physiology	J:326592
	abnormal pancreatic beta cell physiology	J:326592
	abnormal pancreatic islet morphology	J:326592
	abnormal respiratory electron transport chain	J:326592
	decreased circulating insulin level	J:326592
	decreased insulin secretion	J:326592
	decreased pancreatic beta cell mass	J:326592
	hyperglycemia	J:326592
	impaired glucose tolerance	J:326592
	increased fasting circulating glucose level	J:326592

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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