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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Wfdc2
WAP four-disulfide core domain 2
MGI:1914951
26 phenotypes from 4 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Wfdc2em1(IMPC)H/Wfdc2+
C57BL/6NTac-Wfdc2em1(IMPC)H/H 		decreased eosinophil cell number J:211773
enlarged heart J:211773
increased circulating amylase level J:211773
Wfdc2em1(IMPC)H/Wfdc2em1(IMPC)H
C57BL/6NTac-Wfdc2em1(IMPC)H/H 		preweaning lethality, incomplete penetrance J:211773
Wfdc2em1Fcw/Wfdc2em1Fcw
involves: C57 		abnormal lung interstitium morphology J:293623
abnormal lung morphology J:293623
abnormal pulmonary alveolar system morphology J:293623
normal cardiovascular system phenotype J:293623
cyanosis J:293623
decreased blood oxygen saturation level J:293623
decreased pulmonary endothelial cell surface J:293623
decreased type I pneumocyte number J:293623
normal growth/size/body region phenotype J:293623
normal hematopoietic system phenotype J:293623
neonatal lethality, complete penetrance J:293623
respiratory distress J:293623
Wfdc2tm1.1Ohbo/Wfdc2tm1.1Ohbo
involves: C57BL/6NCrlj * CBA/JNCrlj 		abnormal alveolar lamellar body morphology J:282576
abnormal cytokine level J:282576
abnormal lung morphology J:282576
abnormal phospholipid level J:282576
abnormal respiratory epithelium physiology J:282576
abnormal respiratory motile cilium morphology J:282576
atelectasis J:282576
normal cardiovascular system phenotype J:282576
cyanosis J:282576
decreased respiratory motile cilia number J:282576
lung inflammation J:282576
postnatal lethality, complete penetrance J:282576
respiratory distress J:282576
Wfdc2tm1.1Ohbo/Wfdc2tm1b(EUCOMM)Hmgu
involves: C57BL/6N * C57BL/6NCrlj * CBA/JNCrlj 		absent club cells J:282576
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory