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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Chd8
chromodomain helicase DNA binding protein 8
MGI:1915022
36 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Chd8em1(IMPC)Mbp/Chd8+
C57BL/6N-Chd8em1(IMPC)Mbp/MbpMmucd 		abnormal spleen morphology J:211773
decreased locomotor activity J:211773
enlarged lymph nodes J:211773
impaired glucose tolerance J:211773
increased lymphocyte cell number J:211773
Chd8em1(IMPC)Mbp/Chd8em1(IMPC)Mbp
C57BL/6N-Chd8em1(IMPC)Mbp/MbpMmucd 		embryonic lethality prior to organogenesis J:211773
preweaning lethality, complete penetrance J:211773
Chd8tm1.1Csbd/Chd8+
involves: C57BL/6J 		abnormal brain morphology J:267025
abnormal miniature inhibitory postsynaptic currents J:267025
abnormal nervous system electrophysiology J:267025
abnormal neuron physiology J:267025
abnormal social/conspecific interaction behavior J:267025
decreased locomotor activity J:267025
decreased miniature inhibitory postsynaptic current amplitude J:267025
decreased miniature inhibitory postsynaptic current frequency J:267025
excessive vocalization J:267025
increased grooming behavior J:267025
increased miniature inhibitory postsynaptic current frequency J:267025
increased thigmotaxis J:267025
Chd8tm1Kei/Chd8+
involves: 129P2/OlaHsd * C57BL/6J 		abnormal intestinal transit time J:235128
abnormal social investigation J:235128
decreased intestine length J:235128
decreased startle reflex J:235128
increased anxiety-related response J:235128
increased brain weight J:235128
increased prepulse inhibition J:235128
megacephaly J:235128
Chd8tm1Kei/Chd8tm1Kei
involves: C57BL/6 		abnormal inner cell mass morphology J:92968
absent mesoderm J:92968
embryonic growth arrest J:92968
embryonic lethality, complete penetrance J:92968
failure of primitive streak formation J:92968
increased ectoderm apoptosis J:92968
inner cell mass degeneration J:92968
Chd8tm2.1Kei/Chd8+
B6J.129P2-Chd8tm2.1Kei 		abnormal intestinal transit time J:235128
abnormal nervous system development J:235128
abnormal social investigation J:235128
decreased intestine length J:235128
decreased startle reflex J:235128
impaired learning J:235128
increased anxiety-related response J:235128
increased brain weight J:235128
increased prepulse inhibition J:235128
megacephaly J:235128
Chd8tm2.1Kei/Chd8tm2.1Kei
involves: 129P2/OlaHsd * C57BL/6J 		embryonic lethality during organogenesis, complete penetrance J:235128
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory