Kat8 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Kat8
K(lysine) acetyltransferase 8
MGI:1915023

43 phenotypes from 5 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gt(ROSA)26Sor^{tm1(cre/ERT2)Thl}/Gt(ROSA)26Sor⁺ Kat8^tm1Thl/Kat8⁺ involves: 129S1/Sv	abnormal DNA repair	J:128936
	decreased fibroblast proliferation	J:128936
	increased cellular sensitivity to ionizing radiation	J:128936
Gt(ROSA)26Sor^{tm1(cre/ERT2)Thl}/Gt(ROSA)26Sor⁺ Kat8^tm1Thl/Kat8^tm1Thl involves: 129S1/Sv	decreased fibroblast proliferation	J:128936
Kat8^em1(IMPC)Mbp/Kat8⁺ C57BL/6N-Kat8^em1(IMPC)Mbp/MbpMmucd	abnormal kidney morphology	J:211773
	abnormal liver morphology	J:211773
	abnormal lymph node morphology	J:211773
	abnormal vitreous body morphology	J:211773
	cataract	J:211773
	decreased locomotor activity	J:211773
	enlarged lymph nodes	J:211773
	increased circulating cholesterol level	J:211773
	small kidney	J:211773
Kat8^em1(IMPC)Mbp/Kat8^em1(IMPC)Mbp C57BL/6N-Kat8^em1(IMPC)Mbp/MbpMmucd	embryonic lethality prior to organogenesis	J:211773
	preweaning lethality, complete penetrance	J:211773
Kat8^tm1.1Avo/Kat8^tm1.1Avo involves: BALB/cJ * C57BL/6	abnormal chromosome morphology	J:139761
	abnormal inner cell mass apoptosis	J:139761
	absent inner cell mass proliferation	J:139761
	decreased trophectoderm cell proliferation	J:139761
	embryonic lethality between implantation and somite formation, complete penetrance	J:139761
	increased mitotic index	J:139761
Kat8^tm1.2Avo/Kat8^tm1.2Avo Tg(Nes-cre)1Kln/0 involves: C57BL/6 * SJL	abnormal brain vasculature morphology	J:291094
	abnormal cerebral cortex morphology	J:291094
	abnormal embryonic/fetal subventricular zone morphology	J:291094
	abnormal pericyte morphology	J:291094
	enlarged lateral ventricles	J:291094
	hemorrhage	J:291094
	increased fatty acids level	J:291094
	lethality during fetal growth through weaning, incomplete penetrance	J:291094
	postnatal lethality, complete penetrance	J:291094
Kat8^tm1Thl/Kat8^tm1Thl Amhr2^tm3(cre)Bhr/Amhr2⁺ involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6	normal reproductive system phenotype	J:242000
Kat8^tm1Thl/Kat8^tm1Thl Tg(Gdf9-icre)5092Coo/0 involves: 129S1/Sv * C57BL/6	abnormal epigenetic regulation of gene expression	J:242000
	abnormal female germ cell physiology	J:242000
	abnormal oocyte morphology	J:242000
	abnormal oogenesis	J:242000
	decreased oocyte number	J:242000
	decreased ovary weight	J:242000
	female infertility	J:242000
	impaired ovarian folliculogenesis	J:242000
	increased atretic ovarian follicle number	J:242000
	increased female germ cell apoptosis	J:242000
	oxidative stress	J:242000
	small ovary	J:242000
Kat8^tm2Thl/Kat8^tm2Thl involves: 129S1/Sv	abnormal embryo development	J:128936
Kat8^tm2Thl/Kat8^tm2Thl involves: 129S1/Sv	embryonic lethality between implantation and somite formation, complete penetrance	J:128936

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24