Atg3 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Atg3
autophagy related 3
MGI:1915091

16 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Atg3^tm1.1Ywh/Atg3^tm1.1Ywh Gt(ROSA)26Sor^{tm1(cre/ERT)Brn}/Gt(ROSA)26Sor⁺ involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJaeSor * C57BL/6	abnormal T cell morphology	J:172749
	increased T cell apoptosis	J:172749
Atg3^tm1.1Ywh/Atg3^tm1.1Ywh Tg(Lck-cre)548Jxm/0 involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * CBA	abnormal T cell morphology	J:172749
	decreased CD4-positive, alpha-beta T cell number	J:172749
	decreased CD8-positive, alpha-beta T cell number	J:172749
	decreased T cell proliferation	J:172749
	impaired autophagy	J:172749
	increased T cell apoptosis	J:172749
	oxidative stress	J:172749
	spleen hypoplasia	J:172749
	thymus hypoplasia	J:172749
Atg3^{tm1b(EUCOMM)Hmgu}/Atg3^{tm1b(EUCOMM)Hmgu} C57BL/6N-Atg3^{tm1b(EUCOMM)Hmgu}/Cnrm	preweaning lethality, complete penetrance	J:211773
Atg3^tm1Kmts/Atg3⁺ involves: C57BL/6NCrlj * CBA/JNCrlj	abnormal autophagosome formation	J:215884
Atg3^tm1Kmts/Atg3^tm1Kmts involves: C57BL/6NCrlj * CBA/JNCrlj	abnormal autophagy	J:215884
	abnormal circulating amino acid level	J:215884
	decreased birth weight	J:215884
	increased susceptibility to induced morbidity/mortality	J:215884
	neonatal lethality, complete penetrance	J:215884

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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