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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Atg3
autophagy related 3
MGI:1915091
16 phenotypes from 3 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Atg3tm1.1Ywh/Atg3tm1.1Ywh
Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJaeSor * C57BL/6 		abnormal T cell morphology J:172749
increased T cell apoptosis J:172749
Atg3tm1.1Ywh/Atg3tm1.1Ywh
Tg(Lck-cre)548Jxm/0
involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * CBA 		abnormal T cell morphology J:172749
decreased CD4-positive, alpha-beta T cell number J:172749
decreased CD8-positive, alpha-beta T cell number J:172749
decreased T cell proliferation J:172749
impaired autophagy J:172749
increased T cell apoptosis J:172749
oxidative stress J:172749
spleen hypoplasia J:172749
thymus hypoplasia J:172749
Atg3tm1b(EUCOMM)Hmgu/Atg3tm1b(EUCOMM)Hmgu
C57BL/6N-Atg3tm1b(EUCOMM)Hmgu/Cnrm 		preweaning lethality, complete penetrance J:211773
Atg3tm1Kmts/Atg3+
involves: C57BL/6NCrlj * CBA/JNCrlj 		abnormal autophagosome formation J:215884
Atg3tm1Kmts/Atg3tm1Kmts
involves: C57BL/6NCrlj * CBA/JNCrlj 		abnormal autophagy J:215884
abnormal circulating amino acid level J:215884
decreased birth weight J:215884
increased susceptibility to induced morbidity/mortality J:215884
neonatal lethality, complete penetrance J:215884
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory