Rubcn Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rubcn
RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein
MGI:1915160

26 phenotypes from 1 allele in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rubcn^em1Dgre/Rubcn^em1Dgre C57BL/6-Rubcn^em1Dgre	abnormal macrophage physiology	J:261225
	normal hematopoietic system phenotype	J:261225
	normal immune system phenotype	J:261225
	normal mortality/aging	J:261225
Rubcn^em1Dgre/Rubcn^em1Dgre involves: C57BL/6 * C57BL/6N	abnormal circulating chemokine level	J:235399
	abnormal kidney morphology	J:235399
	abnormal macrophage physiology	J:235399
	abnormal renal glomerulus morphology	J:235399
	abnormal spleen morphology	J:235399
	decreased body weight	J:235399
	decreased circulating interleukin-10 level	J:235399
	glomerulonephritis	J:235399
	increased anti-double stranded DNA antibody level	J:235399
	increased anti-nuclear antigen antibody level	J:235399
	increased autoantibody level	J:235399
	increased blood urea nitrogen level	J:235399
	increased CD8-positive, alpha-beta T cell number	J:235399
	increased circulating creatinine level	J:235399
	increased circulating interleukin-1 beta level	J:235399
	increased circulating interleukin-6 level	J:235399
	increased circulating interleukin-12b level	J:235399
	increased IgG level	J:235399
	increased lymphocyte cell number	J:235399
	increased monocyte cell number	J:235399
	increased neutrophil cell number	J:235399
	increased susceptibility to systemic lupus erythematosus	J:235399
	increased urine protein level	J:235399

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24