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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Hcfc2
host cell factor C2
MGI:1915183
8 phenotypes from 4 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Hcfc2em1Btlr/Hcfc2em1Btlr
C57BL/6J-Hcfc2em1Btlr 		decreased tumor necrosis factor secretion J:251008
Hcfc2fkls/Hcfc2+
involves: C57BL/6J 		decreased interferon-beta secretion J:251008
decreased tumor necrosis factor secretion J:251008
Hcfc2fkls/Hcfc2fkls
C57BL/6J-Hcfc2fkls 		abnormal innate immunity J:94077
Hcfc2fkls/Hcfc2fkls
involves: C57BL/6J 		decreased circulating interferon-alpha level J:251008
decreased circulating interferon-beta level J:251008
decreased interferon-beta secretion J:251008
decreased tumor necrosis factor secretion J:251008
increased susceptibility to Herpesvirales infection J:251008
increased susceptibility to Herpesvirales infection induced morbidity/mortality J:251008
increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality J:251008
Hcfc2fkls/Hcfc2min
involves: C57BL/6J 		decreased tumor necrosis factor secretion J:251008
Hcfc2fkls/Hcfc2sca
involves: C57BL/6J 		decreased tumor necrosis factor secretion J:251008
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory