Marchf5 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Marchf5
membrane associated ring-CH-type finger 5
MGI:1915207

18 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Marchf5^tm1.1Ygi/Marchf5^tm1.1Ygi Tg(Emx1-cre)#Ito/0 involves: C57BL/6	abnormal mitochondrial crista morphology	J:284572
	abnormal mitochondrial matrix morphology	J:284572
	abnormal mitochondrial morphology	J:284572
	abnormal neuron morphology	J:284572
	abnormal phospholipid level	J:284572
	abnormal short-term spatial reference memory	J:284572
	astrocytosis	J:284572
	decreased grooming behavior	J:284572
	decreased locomotor activity	J:284572
	decreased mitochondrial size	J:284572
	increased microglial cell activation	J:284572
	oxidative stress	J:284572
Marchf5^{tm1a(EUCOMM)Wtsi}/Marchf5⁺ C57BL/6-Marchf5^{tm1a(EUCOMM)Wtsi}	decreased susceptibility to Riboviria infection induced morbidity/mortality	J:225000
	increased circulating interferon-beta level	J:225000
	increased circulating interleukin-6 level	J:225000
Marchf5^{tm1a(EUCOMM)Wtsi}/Marchf5⁺ C57BL/6N-Marchf5^{tm1a(EUCOMM)Wtsi}/Wtsi	decreased body weight	J:175295
Marchf5^{tm1a(EUCOMM)Wtsi}/Marchf5^{tm1a(EUCOMM)Wtsi} C57BL/6-Marchf5^{tm1a(EUCOMM)Wtsi}	prenatal lethality, complete penetrance	J:225000
Marchf5^{tm1a(EUCOMM)Wtsi}/Marchf5^{tm1a(EUCOMM)Wtsi} C57BL/6N-Marchf5^{tm1a(EUCOMM)Wtsi}/Wtsi	preweaning lethality, incomplete penetrance	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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