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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pold3
polymerase (DNA-directed), delta 3, accessory subunit
MGI:1915217
18 phenotypes from 2 alleles in 2 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Pold3em1Linl/Pold3+
involves: C57BL/6 * DBA/2 		abnormal double-strand DNA break repair J:263620
arrest of male meiosis J:263620
decreased male germ cell number J:263620
decreased telomere length J:263620
decreased testis weight J:263620
increased male germ cell apoptosis J:263620
seminiferous tubule degeneration J:263620
small testis J:263620
spontaneous chromosome breakage J:263620
Pold3em1Linl/Pold3em1Linl
involves: C57BL/6 * DBA/2 		abnormal embryonic tissue physiology J:263620
abnormal trophoblast giant cell proliferation J:263620
absent egg cylinders J:263620
decreased inner cell mass proliferation J:263620
embryonic lethality between implantation and somite formation, complete penetrance J:263620
Pold3tm1b(EUCOMM)Wtsi/Pold3+
C57BL/6N-Pold3tm1b(EUCOMM)Wtsi/Wtsi 		increased circulating insulin level J:211773
Pold3tm1b(EUCOMM)Wtsi/Pold3tm1b(EUCOMM)Wtsi
C57BL/6N-Pold3tm1b(EUCOMM)Wtsi/Wtsi 		embryonic lethality prior to organogenesis J:211773
prenatal lethality prior to heart atrial septation J:211773
preweaning lethality, complete penetrance J:211773
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory