Mpc1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mpc1
mitochondrial pyruvate carrier 1
MGI:1915240

28 phenotypes from 1 allele in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Mpc1^{tm1c(EUCOMM)Wtsi}/Mpc1^{tm1c(EUCOMM)Wtsi} involves: C57BL/6J * C57BL/6N	improved glucose tolerance	J:236662
	increased insulin sensitivity	J:236662
Mpc1^{tm1c(EUCOMM)Wtsi}/Mpc1^{tm1c(EUCOMM)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: C57BL/6 * C57BL/6J * C57BL/6N * DBA	abnormal gluconeogenesis	J:236662
	abnormal mitochondrial physiology	J:236662
	normal behavior/neurological phenotype	J:236662
	decreased body weight	J:236662
	decreased circulating cholesterol level	J:236662
	decreased circulating glucose level	J:236662
	decreased circulating triglyceride level	J:236662
	decreased respiratory quotient	J:236662
	normal homeostasis/metabolism phenotype	J:236662
	improved glucose tolerance	J:236662
	increased circulating ketone body level	J:236662
	increased circulating lactate level	J:236662
	increased fatty acid oxidation	J:236662
	increased triglyceride level	J:236662
Mpc1^{tm1c(EUCOMM)Wtsi}/Mpc1^{tm1c(EUCOMM)Wtsi} Tg(Six3-cre)69Frty/0 involves: C57BL/6N * DBA/2	abnormal cone electrophysiology	J:271892
	abnormal eye physiology	J:271892
	abnormal glucose homeostasis	J:271892
	abnormal metabolism	J:271892
	abnormal Muller cell morphology	J:271892
	abnormal photoreceptor inner segment morphology	J:271892
	abnormal photoreceptor outer segment disc membrane morphology	J:271892
	abnormal retina photoreceptor morphology	J:271892
	abnormal rod electrophysiology	J:271892
	retina degeneration	J:271892
	short photoreceptor outer segment	J:271892
	thin retina inner plexiform layer	J:271892
	thin retina outer nuclear layer	J:271892

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24