Pclaf Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pclaf
PCNA clamp associated factor
MGI:1915276

22 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pclaf^tm1.1Lkd/Pclaf^tm1.1Lkd involves: C57BL/6	abnormal common lymphocyte progenitor cell morphology	J:177782
	abnormal hematopoietic stem cell physiology	J:177782
	abnormal hematopoietic system physiology	J:177782
	decreased bone marrow cell number	J:177782
	decreased common myeloid progenitor cell number	J:177782
	decreased hematopoietic stem cell number	J:177782
	decreased leukocyte cell number	J:177782
	oxidative stress	J:177782
	spleen hypoplasia	J:177782
	thymus hypoplasia	J:177782
Pclaf^{tm1a(EUCOMM)Wtsi}/Pclaf^{tm1a(EUCOMM)Wtsi} C57BL/6N-Pclaf^{tm1a(EUCOMM)Wtsi}/Wtsi	decreased CD11b-high dendritic cell number	J:211773
	decreased dendritic cell number	J:211773
	decreased immature NK cell number	J:211773
	decreased plasmacytoid dendritic cell number	J:211773
	decreased regulatory T cell number	J:211773
	decreased T cell number	J:211773
	impaired glucose tolerance	J:211773
	increased CD11b-low dendritic cell number	J:211773
	increased dendritic cell number	J:211773
	increased mature NK cell number	J:211773
	increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number	J:211773
	increased pro-B cell number	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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